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Chem 425a/552 D. Pavia

Chem 425a/552 D. Pavia. NATURAL PRODUCTS CHEMISTRY. LILAC PROBLEM (Poster Project). 1. This is a group library/ computer search / poster project. 2. The point of the project is for a group of two students to prepare a poster

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Chem 425a/552 D. Pavia

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  1. Chem 425a/552 D. Pavia NATURAL PRODUCTS CHEMISTRY LILAC PROBLEM (Poster Project) 1. This is a group library/ computer search / poster project. 2. The point of the project is for a group of two students to prepare a poster (max size = 54”W x 36”H) about an alkaloid. A poster topic that researches a different type of natural product is possible, but you must obtain my permission in advance. 3. Work in groups of two (2) students. There will be a sign up sheet to avoid any duplication of topic, and so that I will know who is in each group, and who is responsible for each section of the poster. Grad students will work individually. 4. Each student will have full responsibility for one of the following required sections: 1) Structure proof 2) Biosynthesis 3) Chemical Synthesis and joint responsibility for for the third one. It is possible that information may not be available for either (2) or (3). 5. Two additional sections will be prepared by the group: a) Source, history and ethnobotany (short please) b) An annotated bibliography of all sources consulted Place both on an 8-1/2” x 11” sheet of paper (landscape), font size 10 or 12 pt. 6. Each student will receive a grade on their own section (160 points, 80%)

  2. 7. The poster will receive an additional 40 points (20%) for overall quality. 8. I will ask each student to submit and estimate of their contribution to the project and an estimate for the work of the other students; this will be assigned up to 20 additional points (on top of poster grades). 9. Each student’s grade will be the sum of the grade for their section (#6) plus the overall grade (#7), PLUS the points for submitting the estimate form (#8). Up to 220 points may be earned. 10. Posters will be displayed for faculty and students to view. 11. The ultimate poster grade will be mine, based on all the input I receive. Interested faculty will be encouraged to submit comments, as will other students, including those in other groups. 12. Be sure to do a good job! And don’t forget, you may consult me as a resource if you are having difficulties. You must pick a natural product, and it must be approved by me. It is a good idea to get started early. You must select a topic and then find out if all the 3 types of information you need are available. This will take some initial work in the library. If you can’t find the needed information you will need to choose a different topic. Or you may find that all the work is published in German or Chinese! You do not want to find this out in the last couple of weeks. You could run out of time!

  3. EXAMPLES OF POSSIBLE TOPICS lycorine emetine chelidonine saxitoxin (red tide) sparteine ibogamine catharanthine batrachotoxin (frog) reserpine physostigmine colchicine roquefortine (Penicillium) galanthamine quinine strychnine gephyrotoxin (frog) lycopodine glaucine coccinelline (Lady Bug) echinulin erythraline protostephanine gliotoxin (viral RNA inhibitor) betanidin tomatidine solanidine dendrobine tetrodotoxin taxol (Yew tree) zoanthoxanin (Sea Anemone and corals) samandarine nitropolyzonamine (millipede) yohimbine ….. and many others (with permission) Some topics will be more difficult than others because of the complexity of the natural product structure. Also, if the structure is toosimple, it will not make a good topic (you will have little to say). Make sure before you start that the information you need is available in a language you can read.

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