RESEARCH AT THE INSTITUTE OF CHEMISTRY

1. RESEARCH AT THE INSTITUTE OF CHEMISTRY Jim Josephus G. Minglana Institute of Chemistry University of the Philippines Diliman jminglana@chem.upd.edu.ph 04 July 2008

2. Ph.D. FACULTY MEMBERS (28) • Analytical Chemistry (9) • Lilibeth C. Coo • Florian R. Del Mundo • Ma. Pythias Espino • Cynthia Grace C. Gregorio • Cherrie B. Pascual • Leni L. Quirit • Carina Ramos • Jose S. Solis • Florenda S. Valera

3. Biochemistry (2) • Flerida A. Cariño • Jong Wha Lee • Inorganic Chemistry (4) • Ofelia Giron • Jim Josephus G. Minglana • Leon M. Payawan Jr. • Eva Marie A. Ratilla

4. Organic Chemistry (10) • Evangeline C. Amor • Susan R. Arco • Florecita S. De Guzman • Mary Ann E. Arias • Amelia P. Guevara • Christine C. Hernandez • Titos A. O. Quibuyen • Portia Mahal G. Sabido • Florentino C. Sumera • Irene M. Villaseñor

5. Physical Chemistry (3) • Claro T. Llaguno • Elma C. Llaguno • Guillermo M. Nuesca

6. M.S. Faculty Member (1) • Ian Harvey J. Arellano • Inorganic/Materials Chemistry

7. B.S. Faculty Members (xx)

8. Research Areas According to How the Researchers Group Themselves • Analytical and Environmental Chemistry Lab • Analytical Chemistry and Chemical Instrumentation Lab • Bioactive Metabolites Lab • Bioorganic and Natural Products Lab  • Chemical Sensors and Flow Injection Analysis Lab • Computational and Theoretical Chem • Lipid Lab  • Organometallic and Materials Chemistry Research Lab • Polymer Materials Lab • Wet Works Synthetic Organic Lab • Synthetic Organic Chemistry 

9. Nature of Chemistry Research Traditional Groupings Multidisciplinary Analytical Chemistry Bio-Analytical Computational Chemistry Biochemistry Drug Design Nanotechnology Inorganic ChemistryPolymer & Materials Organometallic Chemistry Organic ChemistrySurfaces and catalysis Instrumentation Physical Chemistry Bio-Inorganic Environmental Natural products

10. Suggested Applications-basedResearch Thrusts • Sensing • Energy Generation • Drug Discovery and Design • To change every 3-5 (?) years • To be reviewed yearly

11. Proposed Research Scheme Current Research LabsResearch Thrusts Anal. & Environ. Chem. Anal. & Chem. Instru.Sensing Bioactive Metabolites Bioorganic & Nat. Prod. Chem. Sensors & Flow Energy Generation Injection Anal. Comput. and Theoretical LipidDrug Discovery & Organomet. & Mater. Chem. Design Polymer Materials Wet Works Synthetic Organic Synthetic Organic

13. Synthetic Inorganic and Catalysis Laboratory • Development of Transition Metal Catalysts for the Electrochemical Reductionof Carbon Dioxide • Spectroelectrochemical Properties of Transition Metal Clusters • Development of Photocatalysts for the Degradation of Organic-Based Pollutants • Ring Opening Metathesis Polymerization using Aqueous OrganorutheniumCatalysts

14. Synthetic Inorganic and Catalysis Lab • Development of transition metal catalysts for the electrochemical reduction of CO2 • Spectroelectrochemical properties of transition metal clusters

15. Development of photocatalysts for the degradation of organic-based pollutants • Ring opening metathesis polymerization using aqueous organoruthenium catalysts

16. WET WORKS - SYNTHETIC ORGANIC CHEMISTRY LABORATORY • Development of organic reactions in aqueous media • Development of organic reactions in environmentally benign solvents • Synthesis of water-tolerant chiral catalysts • Synthesis of therapeutic compounds and chemical intermediates • Synthesis of natural products • Synthesis of organic compounds with extreme redox, interesting photo-physical and –chemical properties

17. Liquid Crystals Research Laboratory • Development of novel liquid crystalline materials e.g. Ferroelectric LC, Banana-Shaped LC • Structure-activity studies through molecular modeling and computational chemistry

18. ISCRL: INORGANIC SYNTHESIS & COMPUTATIONAL RESEARCH LABORATORIES • Development of new hybrid materials • Structure-activity studies through molecular modeling and computational chemistry

19. RESEARCH FOCUS • Development of new mesoporous hybrid materials • Structure-activity studies through molecular modeling and computational chemistry. ISCRL :INORGANIC SYNTHESIS & COMPUTATIONAL RESEARCH LABORATORIES

20. AECL - Organic Matter in the Environment Isolation, Structure Elucidation and Mechanisms of Action in the Environment • Humic Substances in the Philippines Environment • Organic Matter in the Environment

21. Analytical and Environmental Research Laboratory • Potentiometric Sensor Based on Molecularly Imprinted Polymer • Chemically Modified Electrodes for Selective Detectionof Environmentally SignificantSubstances • Pesticide Sensors Based on Polysiloxane Modified Graphite Paste Electrodes • Pervaporation-Flow Injection Methods for the Determination of Sulfur Dioxide/Sulfite in Food and Air samples

22. Analytical and Environmental Research Laboratory • Phytoremediation • Heavy metals pollution • Rivers • Landfills • Mussels and oyster • Development of optical chemical sensors for the determination of heavy metals • Wasted feeds as source of organic and inorganic nitrogen and phosphorus in a marine environment

23. Analytical and Environmental Research Laboratory • Method comparison in the determination of Pb, Cr, and Cd contents in Tuna from Quezon and Davao • Investigation of levels of BHT (antioxidant) in different food products by High Performance Liquid Chromatography and Gas Chromatography • UV radiation treatment of POPs pesticides and persistent toxic substances (PTS) • Analysis of bromate and disinfection by-products in recreational and drinking water

24. Analytical and Environmental Research Laboratory • Methods development for the analysis of pesticides in water, soil and sediment • Fate and behavior studies of pesticides and their transformation products in the environment • Determination of Carbamate Residues in Philippine Agricultural Soil and River Water • Analysis of Disinfection By-products in Metro Manila Drinking Water • Biosensors

25. NATURAL PRODUCTS RESEARCH LABORATORY • Antimicrobial Constituent(s) from Planchonia sp./Excoecaria sp. • Discovery and Development of Anticancer Drugs and other Agents for Immuno-Liposome-Mediated Delivery to Breast Cancer Cells: PHILFLORA • Secondary Metabolites from Albizia Species • Anti-Genotoxic Compounds from L. leucocephala • Anti-Diabetic Compounds from Philippine Medicinal Plants

26. BIOACTIVE METABOLITE LABORATORY • Isolation and structure elucidation of biologically active metabolites from Philippine microalgae and entomopathogenic fungi

27. POLYMER CHEMISTRY LABORATORY • Surface Active Antimicrobial Polyurethane • Biodegradable Polymers from Coconut Fatty Acids • Light-Induced Amphiphilic and Antimicrobial Surface Properties of Polyaniline Film • Visible Light-Induced Hydrogen Gas Production from Conducting Polymer Assisted Photolysis of Water and Water Mixtures

28. BIOCHEMISTRY RESEARCH LABORATORY • Mutagenicity and Clastogenicity Potential of Drug Preparations from Philippine Medicinal plants • Study on B2-microglobulin (B2m) fibril formation • Study on the encapsulation of anti-cancer drugs using immunoliposomes for drug delivery

29. BIOMOLECULAR RESOURCES RESEARCH LABORATORY • Enzyme Biotechnology for pesticide degradation • Hydrolytic enzymes from Metarhizium anisopliae • Biomarkers research from Gafrarium dispar and Oxyrichthys microlensis.

30. Organometallic and Materials Chemistry (OmMC) Research Lab • Research in organometallic chemistry, catalysis, materials, coordination chemistry, and related topics

31. Organometallic and Materials Chemistry (OmMC) Research Lab Ru3(CO)12 + excess Ph3SiH  Selected Spectral Data of Product IR: 2000-2150 cm-1 (CO) 1H NMR: -17.8 ppm (RuH) Mass: 1100 [M - 2H]+ m/z Focus on the metal-silicon bond: new discoveries…

32. …to new materials

33. NANOSTRUCTURES AND SURFACE CHEMISTRY RESEARCH LABORATORY • Zeolite/[Ru(bpy)3]2+/TiO2 nanoparticles • Photovoltaic Thin Film from Polypyrrole Micro-array in Al2O3 Template • Bacteriorhodopsin L-b-L Growth