Yaz Birth Control Pill (Generic Drospirenone and Ethinyl Estradiol Tablets)

1. Yaz Birth Control Pill (Generic Drospirenone and Ethinyl Estradiol Tablets) © All Contraceptives

2. Yaz Birth Control Pill (Generic Drospirenone and Ethinyl Estradiol Tablets) Yaz Birth Control Pill (Drospirenone and Ethinyl Estradiol Tablets) is an estrogen/progestin COC, indicated for use by women to Prevent pregnancy. Yaz is also used to treat symptoms of premenstrual dysphoric disorder (PMDD) for women who choose to use an oral contraceptive for contraception. This medicine also treats moderate acne for women at least 14 years old only if the patient desires an oral contraceptive for birth control. Yaz may make your periods more regular, decrease blood loss and painful periods, and decrease your risk of ovarian cysts. © All Contraceptives

3. Yaz Birth Control Pill (Generic Drospirenone and Ethinyl Estradiol Tablets) © All Contraceptives

4. Yaz Birth Control Pill (Generic Drospirenone and Ethinyl Estradiol Tablets) © All Contraceptives

5. Yaz Birth Control Pill (Generic Drospirenone and Ethinyl Estradiol Tablets) Active Ingredients The active pharmaceutical ingredients contained in Yaz tablets are Drospirenone and Ethinyl Estradiol. Each light pink active tablet contains 3 mg of Drospirenone and 0.02 mg of Ethinyl Estradiol. © All Contraceptives

6. Yaz Birth Control Pill (Generic Drospirenone and Ethinyl Estradiol Tablets) Chemical Structure - Drospirenone © All Contraceptives

7. Yaz Birth Control Pill (Generic Drospirenone and Ethinyl Estradiol Tablets) Chemical Structure - Ethinyl Estradiol © All Contraceptives

8. Yaz Birth Control Pill (Generic Drospirenone and Ethinyl Estradiol Tablets) Yaz Tablets Yaz Tablets are marketed by Bayer Zydus Pharma Private Limited, India and manufactured by Bayer AG, Berlin, Germany. They are available in a box of 28 tablets containing 24 pink active Yaz tablets and 4 white dummy tablets. ( Website: https://www.bayer.com/en/ https://www.bayer.com/en/ ) URL: URL: https://www.allcontraceptives.com/yaz-birth-control-pill.html https://www.allcontraceptives.com/yaz-birth-control-pill.html © All Contraceptives

9. Yaz Birth Control Pill (Generic Drospirenone and Ethinyl Estradiol Tablets) Uses of Yaz Tablets Yaz (Drospirenone and Ethinyl Estradiol tablets) is a combined oral contraceptive, commonly known as a ‘birth control pill’ or ‘the Pill’. Yaz is used to prevent pregnancy. It is also used to treat moderate acne and symptoms of premenstrual dysphoric disorder (PMDD) in women seeking oral contraception Drospirenone and Ethinyl Estradiol combination is used to prevent pregnancy. It is a birth control pill that contains two types of hormones, ethinyl estradiol and drospirenone, and when taken properly, prevents pregnancy. It works by stopping a woman's egg from fully developing each month. The egg can no longer accept a sperm and fertilization (pregnancy) is prevented. URL: URL: https://www.allcontraceptives.com/yaz-birth-control-pill.html https://www.allcontraceptives.com/yaz-birth-control-pill.html © All Contraceptives

10. Yaz Birth Control Pill (Generic Drospirenone and Ethinyl Estradiol Tablets) Uses of Yaz Tablets This medicine is also used to treat premenstrual dysphoric disorder (PMDD) and acne in women at least 14 years of age. PMDD is a severe form of premenstrual syndrome (PMS). Patients with PMDD may have severe emotional and physical symptoms 10 to 14 days before their menstrual flow starts. You may also experience the following benefits: You may also experience the following benefits: • more regular and lighter periods – potentially resulting in a decrease in anaemia (iron deficiency) • a decrease in period pain. • a decrease in your risk of ovarian cysts URL: URL: https://www.allcontraceptives.com/yaz-birth-control-pill.html https://www.allcontraceptives.com/yaz-birth-control-pill.html © All Contraceptives

11. Yaz Birth Control Pill (Generic Drospirenone and Ethinyl Estradiol Tablets) Uses of Yaz Tablets You may also experience the following benefits: You may also experience the following benefits: • improvement in symptoms like bloating, swelling or weight gain related to fluid retention. Some conditions such as pelvic inflammatory disease, ovarian cysts, ectopic pregnancy (where the foetus is carried outside of your womb), lumpy breasts and cancer of the uterus (womb), and ovaries may be less common in women taking the Pill. When taken correctly, it prevents you from becoming pregnant in several ways, including: • inhibiting the egg release by stopping it maturing • changing the cervical mucus consistency, making it more difficult for the sperm to reach the egg. URL: URL: https://www.allcontraceptives.com/yaz-birth-control-pill.html https://www.allcontraceptives.com/yaz-birth-control-pill.html © All Contraceptives

12. Yaz Birth Control Pill (Generic Drospirenone and Ethinyl Estradiol Tablets) Uses of Yaz Tablets Yaz has 24 active (hormone) tablets and 4 inactive tablets, rather than the traditional 21 active tablets and 7 inactive tablets. This means that with Yaz, you take the active (hormone) tablets for three more days. This helps your hormone levels to stay even. URL: URL: https://www.allcontraceptives.com/yaz-birth-control-pill.html https://www.allcontraceptives.com/yaz-birth-control-pill.html © All Contraceptives

13. Yaz Birth Control Pill (Generic Drospirenone and Ethinyl Estradiol Tablets) Recommended Dosage The dosage of Yaz tablets Yaz tablets (Drospirenone and Ethinyl Estradiol Tablets) is given below: Tablets must be taken in the order directed on the package, at about the same time every day, with some liquid if needed. One tablet is taken daily for 28 days. Each subsequent pack is started the day after the last intake of the previous pack. A withdrawal bleed usually starts on day 2 to 3 after starting the placebo tablets (white tablets in the last row) and may not be finished before the next pack is started. No preceding hormonal contraceptive use (in the past month): No preceding hormonal contraceptive use (in the past month): Tablet-taking has to start on day 1 of the woman’s natural cycle (i.e. the first day of her menstrual bleeding). Starting on days 2 to 5 is allowed, but during the first cycle a barrier method is recommended in addition for the first 7 days of tablet-taking. URL: URL: https://www.allcontraceptives.com/yaz-birth-control-pill.html https://www.allcontraceptives.com/yaz-birth-control-pill.html © All Contraceptives

14. Yaz Birth Control Pill (Generic Drospirenone and Ethinyl Estradiol Tablets) Recommended Dosage Yaz tablets (Drospirenone and Ethinyl Estradiol Tablets) is given below: Changing from a combined hormonal contraceptive (combined oral Changing from a combined hormonal contraceptive (combined oral contraceptive), vaginal ring or transdermal patch: contraceptive), vaginal ring or transdermal patch: The woman should start with Yaz preferably on the day after the last active tablet of her previous combined oral contraceptive, but at the latest on the day following the usual tablet-free or inactive tablet interval of her previous combined oral contraceptive. In case a vaginal ring or transdermal patch has been used, the woman should start using Yaz preferably on the day of removal, but at the latest when the next application would have been due. The dosage ofYaz tablets URL: URL: https://www.allcontraceptives.com/yaz-birth-control-pill.html https://www.allcontraceptives.com/yaz-birth-control-pill.html © All Contraceptives

15. Yaz Birth Control Pill (Generic Drospirenone and Ethinyl Estradiol Tablets) Contraindications Yaz is contraindicated in patients with a hypersensitivity to Drospirenone, Ethinyl Estradiol or any other component of this medication. Yaz tablets are also contraindicated in the following cases: Yaz tablets are also contraindicated in the following cases: Renal impairment or adrenal insufficiency A high risk of arterial or venous thrombotic diseases Undiagnosed abnormal uterine bleeding Breast cancer or other estrogen- or progestin-sensitive cancer Liver tumors or liver disease Pregnancy URL: URL: https://www.allcontraceptives.com/yaz-birth-control-pill.html https://www.allcontraceptives.com/yaz-birth-control-pill.html © All Contraceptives

16. Yaz Birth Control Pill (Generic Drospirenone and Ethinyl Estradiol Tablets) Storage Instructions Yaz tablets (Drospirenone and Ethinyl Estradiol tablets) have to be stored at controlled room temperature i.e. from 20°C to 25°C (68°F to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F). Keep this as well as all other medicines away from children and pets. URL: URL: https://www.allcontraceptives.com/yaz-birth-control-pill.html https://www.allcontraceptives.com/yaz-birth-control-pill.html © All Contraceptives

17. Yaz Birth Control Pill (Generic Drospirenone and Ethinyl Estradiol Tablets) Warnings Vascular risks: Stop Yaz if a thrombotic event occurs. Stop at least 4 weeks before and through 2 weeks after major surgery. Start no earlier than 4 weeks after delivery, in women who are not breastfeeding. Hyperkalemia: Drospirenone (DRSP) has antimineralocorticoid activity. Do not use in patients predisposed to hyperkalemia. Check serum potassium level during the first treatment cycle in women on long- term treatment with medications that may increase serum potassium. Liver disease: Discontinue Yaz if jaundice occurs. High blood pressure: Do not prescribe Yaz for women with uncontrolled hypertension or hypertension with vascular disease. URL: URL: https://www.allcontraceptives.com/yaz-birth-control-pill.html https://www.allcontraceptives.com/yaz-birth-control-pill.html © All Contraceptives

18. Yaz Birth Control Pill (Generic Drospirenone and Ethinyl Estradiol Tablets) Warnings Carbohydrate and lipid metabolic effects: Monitor prediabetic and diabetic women taking Yaz. Consider an alternate contraceptive method for women with uncontrolled dyslipidemia. Headache: Evaluate significant change in headaches and discontinue Yaz if indicated. Uterine bleeding: Evaluate irregular bleeding or amenorrhea. Women with a history of depression should be carefully observed and Yaz discontinued if depression recurs to a serious degree. The use of COCs may change the results of some laboratory tests, such as coagulation factors, lipids, glucose tolerance, and binding proteins. Women on thyroid hormone replacement therapy may need increased doses of thyroid hormone because serum concentrations of thyroid-binding globulin increase with use of COCs. URL: URL: https://www.allcontraceptives.com/yaz-birth-control-pill.html https://www.allcontraceptives.com/yaz-birth-control-pill.html © All Contraceptives

19. Yaz Birth Control Pill (Generic Drospirenone and Ethinyl Estradiol Tablets) Side Effects The most frequent Yaz side effects with an incidence rate of 2% or greater in contraception and acne clinical trials were: headache/migraine (6.7%), menstrual irregularities (4.7%), nausea/vomiting (4.2%), breast pain/tenderness (4.0%) and mood changes (2.2%). The most frequent Yaz side effects with an incidence rate of 2% or greater in PMDD (Premenstrual Dysphoric Disorder) clinical trials were: menstrual irregularities (24.9%), nausea (15.8%), headache (13.0%), breast tenderness (10.5%), fatigue (4.2%), irritability (2.8%), decreased libido (2.8%), increased weight (2.5%), and affect lability (2.1%). URL: URL: https://www.allcontraceptives.com/yaz-birth-control-pill.html https://www.allcontraceptives.com/yaz-birth-control-pill.html © All Contraceptives

20. Yaz Birth Control Pill (Generic Drospirenone and Ethinyl Estradiol Tablets) Overdose There have been no reports of serious ill effects from overdose, including ingestion by children. Overdosage may cause withdrawal bleeding in females and nausea. Drospirenone (DRSP) is a spironolactone analogue which has antimineralocorticoid properties. Serum concentration of potassium and sodium, and evidence of metabolic acidosis, should be monitored in cases of overdose. URL: URL: https://www.allcontraceptives.com/yaz-birth-control-pill.html https://www.allcontraceptives.com/yaz-birth-control-pill.html © All Contraceptives

21. Yaz Birth Control Pill (Generic Drospirenone and Ethinyl Estradiol Tablets) Yaz Tablets During Pregnancy Yaz tablets (Drospirenone and Ethinyl Estradiol tablets) has been classified by the US FDA as Pregnancy Category X. There is little or no increased risk of birth defects in women who inadvertently use COCs during early pregnancy. Epidemiologic studies and meta-analyses have not found an increased risk of genital or non- genital birth defects (including cardiac anomalies and limb-reduction defects) following exposure to low dose COCs prior to conception or during early pregnancy. The administration of COCs to induce withdrawal bleeding should not be used as a test for pregnancy. COCs should not be used during pregnancy to treat threatened or habitual abortion. URL: URL: https://www.allcontraceptives.com/yaz-birth-control-pill.html https://www.allcontraceptives.com/yaz-birth-control-pill.html © All Contraceptives

22. Yaz Birth Control Pill (Generic Drospirenone and Ethinyl Estradiol Tablets) Yaz Tablets Yaz Tablets (Drospirenone and Ethinyl Estradiol Tablets) marketed by Bayer Zydus Pharma Private Limited, India and manufactured by Bayer AG, Berlin, Germany. URL: URL: https://www.allcontraceptives.com/yaz-birth-control-pill.html https://www.allcontraceptives.com/yaz-birth-control-pill.html © All Contraceptives