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Adult Stem Cells

Adult Stem Cells. Adult Stem Cells are undifferentiated cells found throughout the body in adult tissue. Also known as somatic stem cells, these cells are multipotent. What’s the difference between Multipotent and Pluripotent stem cells?.

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Adult Stem Cells

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  1. Adult Stem Cells • Adult Stem Cells are undifferentiated cells found throughout the body in adult tissue. • Also known as somatic stem cells, these cells are multipotent.

  2. What’s the difference between Multipotent and Pluripotent stem cells?

  3. Multipotent- These cells can only give rise to cells in their own lineage or closely related family of cells. • Pluripotent-These cells are descendants of totipotent stem cells and can give rise to cells of the three germ layers: endoderm, mesoderm, and ectoderm. They have no contribution to extraembryonic membranes or the placenta.

  4. What are the three classes of Hematopoetic Stem Cells

  5. Lymphocyte-biased HSC’s (Ly-bi) • High L/M ratio. Lymphocytes >10. • 2. Myeloid-biased HSC’s (My-bi) • Low L/M ratio. Lymphocytes >0, <3. • 3. Balanced HSC’s (Bala) • Lymphocytes > or = 3 and < or = 10

  6. Lymphocytes(Lymphoids) • There are three types of Lymphocytes under the two classes, Large and small lymphocytes. • T-cells (thymus-derived cells)-Small Lymphocyte • Mostly involved in cell-mediated immunity • 2. B-cells (bursa-derived cells)- Small Lymphocyte • Mostly involved in humoral immunity • 3. Natural Killer cells (NK Cells)- Large Lymphocyte • Play a major role in defending the host from tumors and virally infected cells.

  7. Monocytes(Myeloids) • These cells make up 3-8 percent of leukocytes or white blood cells. • Main purpose is to be used in the innate immune system against pathogens and other harmful cells. • Migrate into tissue where they are then differentiated into macrophages which do the same job as monocytes. • Activate Lymphocytes.

  8. What are some Hematopoietic Stem Cell sources?

  9. Bone Marrow • First stem cell source ever used, back in 1945. still in use today.

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