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Proteins

Proteins. Chapter 5 Big Idea #2: Structure Meets Function. Basic Unit of Proteins. Amino Acid: Review: What are the constant domains of an amino acid? What is the variable region?. Types of Amino Acids. What functional groups can you recognize in the variable regions?

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Proteins

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  1. Proteins Chapter 5 Big Idea #2: Structure Meets Function

  2. Basic Unit of Proteins • Amino Acid: • Review: • What are the constant domains of an amino acid? • What is the variable region?

  3. Types of Amino Acids What functional groups can you recognize in the variable regions? How might these impact how the variable region functions?

  4. How does the amino acid chain dictate protein structure?

  5. Modeling Activity Let’s use pipecleaners to model protein structure. What limitations do we have?

  6. What impacts each level of structure?

  7. Key Protein Functions • Can you give an example of each? (In case a multiple choice gives examples instead of categories?!) • Enzymes • Hormone • Receptor • Contractile • Defensive • Transport • Storage • Structural

  8. Structure Meets Function • Case Study: Hemoglobin • What differs? • How might this cause such a significant change in protein structure?

  9. Sickle Cell Disease

  10. Structure Meets Function • Case Study: CJD and Prions • Prions: Misfolded proteins • Can be infectious agents!

  11. Protein Project!!! • Goal: • To connect Big Ideas #1 & 3 (Evolution and continuity of proteins) to Big idea #2 (How proteins work) Work in Pairs By Function • Your job is to find TWO examples for each function and present a poster session to connect the two examples. • Research structure meets function using primary sources and figures from primary sources. • Research evolution using a BLAST to find and compare similar protein sequences in various organisms.

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