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Heparin-associated 30 Day Mortality

Heparin-associated 30 Day Mortality. Zarychanski et al, CCM 2008;36:2973-9. Heparin-Associated 30 Day Mortality. Adjusted Cox Proportional hazards of mortality with therapeutic dose IV heparin. Zarychanski et al, CCM 2008;36:2973-9. Effect of IV Heparin: 30 Day Mortality. p < .01. p = .05.

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Heparin-associated 30 Day Mortality

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  1. Heparin-associated 30 Day Mortality Zarychanski et al, CCM 2008;36:2973-9

  2. Heparin-Associated 30 Day Mortality Adjusted Cox Proportional hazards of mortality with therapeutic dose IV heparin Zarychanski et al, CCM 2008;36:2973-9

  3. Effect of IV Heparin: 30 Day Mortality p < .01 p = .05 Zarychanski et al, CCM 2008;36:2973-9

  4. 48 703 ICU admissions from 1989-2005 Inclusion Criteria: Meet 1991 SCCM/ACCP Criteria for septic shock 2912 Identified cases of Septic Shock Level 1 Exclusion: (n = 255 ) 112 Mixed shock states with clinically significant cardiogenic, hemorrhagic, or obstructive elements 143 Definitive admitting diagnosis of ACS, MI or pulmonary embolus 2657 Confirmed cases of Septic Shock Level 2 Exclusion: (n = 331) 157 Patients died within 48 hours of admission 174 Patients who received heparin >48 hour after admission 2326 – Final study cohort 1604 - Did not receive therapeutic dose heparin 722 - Received intravenous therapeutic dose heparin Effect of IV Heparin: 30 Day Mortality Zarychanski et al, CCM 2008;36:2973-9

  5. Effect of IV Heparin: Hazard Ratios for 30 Day Mortality Zarychanski et al, CCM 2008;36:2973-9

  6. APACHE II Quartile P value 3-19 0.36 20-24 0.43 25-29 0.02 30-53 0.02 3-53 0.005 1 0.25 4.0 increased decreased risk risk Hazard Ratio Effect of IV heparin and aPC: Hazard Ratios for 30 Day Mortality Heparin aPC Bernard et al, NEJM 2001 Zarychanski et al, CCM 2008;36:2973-9

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