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Combination of Fermented Soy with Chemo-Therapy -Results of a Phase I Study -

Combination of Fermented Soy with Chemo-Therapy -Results of a Phase I Study -. Dr. Ursula Jacobs Klinik am Alpenpark D-83707 Ringsee am Tegernsee Germany PD Dr.Dr. Uwe D Rohr MED19 Medical Center Wien-Grinzing Austria. Vienna Dec. 7 th 2007. Soy suppresses

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Combination of Fermented Soy with Chemo-Therapy -Results of a Phase I Study -

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  1. Combination of Fermented Soy with Chemo-Therapy -Results of a Phase I Study - Dr. Ursula Jacobs Klinik am Alpenpark D-83707 Ringsee am Tegernsee Germany PD Dr.Dr. Uwe D Rohr MED19 Medical Center Wien-Grinzing Austria Vienna Dec. 7th 2007

  2. Soy suppresses Inflammation and Cancer Cancer Soy-Isoflavones MAPK MAPK NFkB NFkB IL-6 APOPTOSIS IL-6 APOPTOSIS Cancer Inflammation Cancer Inflammation Cachexia Depression Imhof et al, 2006 Haegemans et al, 2006 Sartyr et al, 2007

  3. Chemo-Therapy increases Inflammation and Reduces Apoptosis Chemo-Therapy Cancer Soy-Isoflavone MAPK MAPK MAPK NFkB NFkB NFkB IL-6 APOPTOSIS IL-6 IL-6 APOPTOSIS APOPTOSIS Inflammation Cancer Cancer Inflammation Cancer Inflammation Cachexia Depression Cachexia Depression Imhof et al, 2006 Haegemans et al, 2006 Sartyr et al, 2007

  4. Patient-Characteristics

  5. Summary of Molecular Results Combination-Therapy Fermented Soy + Chemo-Therapy * 3Month Therapy Phase I Study* Rohr , et al 2007 , unpublished results

  6. Inhibition of Cell Cycle Isoflavone Tamoxifen

  7. facher Anstieg 300 200 100 0 ER-ß Fermented Soy and ER-ß Expression in dissimated cellsn=5 0 1,5 3 Zeit (Monate) Patient consume Isoflavones regularly Patients with high GLEASON Factor (High Malignicy)

  8. Fermented Soy and Classical Cancer Parameter PSA-Value 300 200 100 0 0 1,5 3 Zeit (Monate)

  9. Cachexia is the leading death among cancer patients Forschung und Praxis 435; 2006 S 16

  10. Cachexia: Part of Aging Process • Chronic Inflammatory Aging Diseases and Cancer: Estrogen-Receptor-Beta (ER-ß) Deficiencies ER-ß suppresses suppresses Cancer Inflammation (IL-6, TNF-...) Arteriosclerosis, Blood Pressure, Dementia, Osteoporosis, Cystitis , etc. Cachexia

  11. Cytocines cause Cachexia Morley et al Am J Clin Nutr 2006;83:735– 43

  12. Inflammation Marker TNF-can be reduced by Soy - Isoflavones 120 mg Genistein / dayn=16 postmenopausa women Base line Isoflavone consumption after consumtion Times (Weeks) Rohr , et al 2007

  13. Cachexia and Apoptosis Combination (Fermented Soy + Chemo-Therapy) Phase I Study* * 3Month Therapy Rohr , et al 2007 , unpublished data

  14. Appetite Increaseby fermented Soy during Chemotherapyin Breast Cancer Patients EORTC QLQ-C30 (Version1) after 3 Month Rohr , et al 2007 , nicht veröffentichte Ergebnisse

  15. Body Weight Increase by fermented Soy and Chemotherapy after 3 Month EORTC QLQ-C30 (Version1) Mamma Ca Prostate Ca Ovarian Ca Body Weight Increase (%) Body Weight Increase (%) Body Weight Increase (%) 130 120 110 100 130 120 110 100 130 120 110 100 130 120 110 100 130 120 110 100 130 120 110 100 Rohr , et al 2007 , nicht veröffentichte Ergebnisse

  16. Soy-Isoflavone do not act like Estrogens !!! Cerebral hemisphäre : ER-ß Rezeptoren cognition Hypothalamus : ER-ß und Testosteron Rezeptoren Ängstlichkeit, Depression, Stress, PMS, ADD/ADHD, Hormone Regulation & mehr Stress accompanies Cancer Stress reduction silences Immune-System

  17. Psychotropic-Effects of Fermented Soyin Cancer Therapy (with Chemo-Therapy) documented by a standardized QuestionaireEORTC QLQ-C30 (Version1) Mamma Ca after 3 Month after 3 Month Uwe Rohr, unreported results, 2007

  18. Psychotropic-Effects of Fermented Soyin Cancer Therapy (with Chemo-Therapy)documented by a standardized QuestionaireEORTC QLQ-C30 (Version1) Mamma Ca after 3 Month Uwe Rohr, unreported results, 2007

  19. ER-ß , ER-   CNS ER- ER-ß Bones ER- ER-ß Lung ER- ER-ß Arteries ER-ß Liver ER- Mamma ER- ER-ß Colon ER-ß ER- Bladder ER-ß Prostate ER- ER-ß Uterus ER- Testicles ER- ER-ß Ovaries ER- ER-ß Uwe D Rohr , GYNE 2006

  20. Improvement of ER-ß related Diseases by fermented Soy (Not including psychotropic effects) -Cystitis (3 cases in breast cancer cases) -sleep improvement (8 x = 75 % of all participants) -no poll allergy (5 cases) -improved cognition (75%) Joint pain -no pain in finger joints (2x) -no backpain (1x) General observation in man and women -Improved skin appearances -improved nails and hairs

  21. Patient U.L Date of Birth.: 14.5.58 08/03 First Diagnosis: Mamma CA, Primary tumor Tumor-Excission, plus Axilla-Dissection 6 x cycles Chemotherapie, 3 x cycles Zoladex 11/3 Liver metastasen, Chemo-Embolisation, Prof. Vogel , Frankfurt 01/05 Leber Metatstasen: komplette Remission of primary tumor 26.07.06 New liver Metastasis Begin 04/07 HAELAN 951

  22. Tumor-Size Reduction by Fermented Soy Patient U.L. Liver Tumor -Diameter (cm) 5 Fermented Soy Strong Mood Improvement Fermented Soy Strong Mood Improvement Depression 0 25.4.2007 2.8.2007 12/07 Uwe Rohr et al, unreported results, 2007

  23. Tumor-Size, Depression, Body-Weight And fermented Soy Body Weigth Improvement (kg) strong mood improvement strong mood improvement Fermented Soy Fermented Soy Liver Tumor -Diameter (cm) Strong depression 10kg 5 5kg 0 25.4.2007 2.8.2007 12/07 Uwe Rohr et al , unreported results, 2007

  24. Can Dissiminated Breast Cancer-Cells be reduced by by fermented Soy ? (Cancer Stem-Cells) Patient SM, 48 Years Fermented Soy Treatment Cell Numbers per (ml) ongoing 5000 0 25.4.2007 2.8.2007 12/07 Uwe Rohr et al , unreported results, 2007

  25. Phase I Study In Vienna (Schematic description) Cancer Stem-Cell Less malignant Cancer Stem Cell non cancerogenic cancer cell non cancerogenic cancer cell Cavities Fermented Soy 3 month Residual-Tumor Invasive Carcinoma Invasive Cacinoma Numbers Malignity In blood In blood Cavities Residual-Tumor Metastasis Metastasis

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