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Role of Metabolic Reprogramming in Pulmonary Innate Immunity and Its Impact on Lung Diseases

Amarjit Mishra also pursued research in this area to better comprehend this. He had demonstrated that suppression of glycolysis using 2-Deoxy-d-glucose in an ex vivo research reversed IL-1 production, demonstrating that neutrophil actions have been discovered to be mediated via this process.<br>

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Role of Metabolic Reprogramming in Pulmonary Innate Immunity and Its Impact on Lung Diseases

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  1. Role of Metabolic Reprogramming in Pulmonary Innate Immunity and Its Impact on Lung Diseases It may be possible to find novel treatment targets by understanding how lung illness alters the metabolism of innate immune cells. This is crucial since there are currently clinically tested medications for the treatment of other disorders, like cancer, that target certain metabolic pathways. In his most recent research, Amarjit Mishra of Auburn University.

  2. One of Amarjit Misrha’s most important contributions has been the improvement of knowledge regarding the function of metabolic reprogramming of the glycolytic enzyme Pyruvate Kinase M2 in enhancing the pulmonary immune system.

  3. It was found that the FoxO1 defective alveolar macrophages had an M2 similar phenotype, and it was determined that the change in polarisation was via downregulation of glycolytic capability. Hence demonstrating that metabolic reprogramming of Pyruvate Kinase M2 has an active function in supplying innate immunity in the case of lung illnesses.

  4. Amarjit Mishra and the team have concentrated on the function of mTOR kinase and the metabolic reprogramming of naive T cells. The mammalian target of rapamycin (mTOR) kinase was found to play a key role in T cell polarisation through dendritic cells and intrinsic T cells, which drive metabolic reprogramming.

  5. Amarjit Mishra has conducted extensive research on the subjects listed above as well as the impact of metabolic reprogramming in neutrophils on the emergence of lung illnesses. It is well known that neutrophils get the majority of their energy from aerobic glycolysis. Source:-https://fgtnews.com/role-of-metabolic-reprogramming-in-pulmonary-innate-immunity-and-its-impact-on-lung-diseases/

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