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Mid-IR laser imaging for molecular recognition in security and medical applications

Mid-IR laser imaging for molecular recognition in security and medical applications. Anadi Mukherjee. I nfra S ign Fremont, CA. I nfra S ign. Lasers, Optics & Photonics, Oct 7-9, 2013. I nfra S ign. Revealing the Invisible for a Safer World. Mid-IR laser imaging for

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Mid-IR laser imaging for molecular recognition in security and medical applications

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  1. Mid-IR laser imaging for molecular recognition in security and medical applications Anadi Mukherjee InfraSign Fremont, CA InfraSign Lasers, Optics & Photonics, Oct 7-9, 2013

  2. InfraSign Revealing the Invisible for a Safer World Mid-IR laser imaging for Molecular Recognition • Security • HAZMATs • Food Safety • Medical • Tagless Pathology • Pharma QC/QA Hand-held, battery operated system www.infrasign.com InfraSign Lasers, Optics & Photonics, Oct 7-9, 2013 2

  3. MIRIS – Mid-IR Imaging Spectroscopy Diffuse Reflection Trace Molecules Or Molecular Modifications Laser Camera l2 l1 Strong fundamental Vibrations (MIR) vs. Weak Overtone (NIR) or Raman l3 l4 Hyperspectral Imaging 3 Lasers, Optics & Photonics, Oct 7-9, 2013

  4. Security • Trace HAZMATS & Narcotics • Medical • Food Safety - Biocontamination Sensor • Pharma - Real-time in-line QuantitativeQC/QA • Laser Pathology - Antibody-free Diagnosis • Body Fluids • Tissues – Cancer Biomarkers • In-vivo diagnosis/surgery, New Microarrays InfraSign Lasers, Optics & Photonics, Oct 7-9, 2013 4

  5. Security Lasers, Optics & Photonics, Oct 7-9, 2013 5

  6. SPoT - Sensitive Picture of Traces 12” Hand-held, battery operated, 9”x7”x4”, < 4 lbs Lasers, Optics & Photonics, Oct 7-9, 2013 6

  7. R  AN 9.25um Urea Nitrate 7.38um 9.5um TNT Sugar Lasers, Optics & Photonics, Oct 7-9, 2013 8

  8. 3 QCLs 9.5 mm 7.38 mm DFB FP DFB 9.25 mm 7

  9. SPoT raw image results of AN trace on polyethylene Very thin (cloudy) film of AN on polyethylene film R  Absorption 9.25um 9.5um 7.38um Incident beams 6” 7.38um 9.25um 9.5um Lasers, Optics & Photonics, Oct 7-9, 2013 9

  10. Validation • First explosive trace imaging system sold for use by US Navy • Customer quote: “(SPoT) continues to function well despite the traveling it has done.  The hardware has proven to be remarkably robust.” Lasers, Optics & Photonics, Oct 7-9, 2013 10

  11. Safety & Medical Industrial Plant Safety/TICs Food Safety Pharmaceutical QC/QA Medical Imaging Lasers, Optics & Photonics, Oct 7-9, 2013 11

  12. Fundamental Biomolecular Vibrations Proteins Overlap Sugars Fatty Acids InfraSign Lasers, Optics & Photonics, Oct 7-9, 2013 12

  13. Hyperspectral Imaging of Serum Protein ROC Curve PD of 99% Sensitivity Specificity PFA of 10-2 (PD of 99%) 77ug/cm2 Anadi Mukherjee et al “Spectroscopic imaging of serum proteins using quantum cascade lasers”, Journal of Biomedical Optics 18(3), 036011 (March 2013).

  14. Acknowledgements • Pathology Department UCSF • Professor Tarik Tihan, UCSF • Manu Prasanna • Steve Barnett • Quentin Bylund • Biswaroop Mukherjee • Block Engineering – Petros Kotidis • Adtech Optics – Mariano Troccoli • ThorLabs – John Bruno Thanks Lasers, Optics & Photonics, Oct 7-9, 2013 14

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