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Formation of a Concentrated Urine

Formation of a Concentrated Urine. ADH present. 900. Na + Cl -. 1100. Fig. 23.19 modified . Antidiuretic Hormone in the formation of a concentrated urine. principal cell. Koeppen and Stanton, Renal Physiology . Medullary Gradient. two solute hypothesis NaCl urea

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Formation of a Concentrated Urine

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  1. Formation of a Concentrated Urine ADH present 900 Na+ Cl- 1100 Fig. 23.19 modified

  2. Antidiuretic Hormonein the formation of a concentrated urine principal cell Koeppen and Stanton, Renal Physiology

  3. Medullary Gradient • two solute hypothesis • NaCl • urea • formation of gradient inhibited by • osmotic diuresis • The presence of unreabsorbed solutes decreases the concentration of Na+, thereby decreasing the reabsorption of Na+. • protein deficiency • less urea  smaller medullary gradient • loop diuretics

  4. Functions of ADH • Formation of a concentrated urine • increased permeability of collecting duct to H2O • increased permeability of collecting duct to urea • increased reabsorption of NaCl by thick ascending limb of the loop of Henle

  5. Posterior Pituitaryneurohypophysis Fig. 17.4

  6. Regulation of ADH Secretion Stimulates hypothalamic osmoreceptors  firing of atrial stretch receptors Fig. 24.4 Fig 24.3

  7. Diuretics Summary Katzung, Basic and Clinical Pharmacology

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