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Phex mutations alter the responsiveness of bone cells to extracellular phosphate concentrations

Phex mutations alter the responsiveness of bone cells to extracellular phosphate concentrations. Osteoscoop - Issue N°235 – May 2012. Osteoblast. Serum. [FGF23] Phex >> [FGF23] WT. Phex K496X. Low phosphate reabsorption = Hypophosphatemia. FGF23 mRNA. FGF 23. FGF 23. FGF 23. FGF

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Phex mutations alter the responsiveness of bone cells to extracellular phosphate concentrations

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  1. Phex mutations alter the responsiveness of bone cells to extracellular phosphate concentrations Osteoscoop - Issue N°235 – May 2012

  2. Osteoblast Serum [FGF23]Phex>> [FGF23]WT PhexK496X Low phosphate reabsorption = Hypophosphatemia FGF23 mRNA FGF 23 FGF 23 FGF 23 FGF 23 FGF 23 FGF 23 FGF 23 FGF 23 FGF 23 FGF 23 P

  3. Osteoblast Serum [FGF23]Phex>> [FGF23]WT PhexK496X Low phosphate reabsorption = Hypophosphatemia FGF23 mRNA FGF 23 FGF 23 FGF 23 FGF 23 FGF 23 FGF 23 FGF 23 FGF 23 FGF 23 FGF 23 FGF 23 FGF 23 FGF23 degraded P P Serum FGF23 mRNA [FGF23]Galnt3< [FGF23]WT Galnt3-/- High phosphate reabsorption = Hyperphosphatemia

  4. Osteoblast Serum [FGF23]Phex>> [FGF23]WT PhexK496X Low phosphate reabsorption = Hypophosphatemia Fgf23 mRNA FGF 23 FGF 23 FGF 23 FGF 23 FGF 23 FGF 23 FGF 23 FGF 23 FGF 23 FGF 23 FGF 23 FGF 23 FGF 23 FGF 23 FGF 23 FGF 23 FGF 23 FGF 23 FGF 23 FGF 23 FGF23 degraded P P P Serum Fgf23 mRNA [FGF23]Galnt3< [FGF23]WT Galnt3-/- High phosphate reabsorption = Hyperphosphatemia Serum PhexK496X [FGF23]Galnt3 Phex> [FGF23]WT Galnt3-/- Moderate phosphate reabsorption = Moderate Hypophosphatemia Fgf23 mRNA

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