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Human Papillomavirus (HPV)

Human Papillomavirus (HPV). Wed, Nov 21 2007 Tanjung Jaya, Indonesia. The Virus. Papovaviridae infect skin and mucous membrane entry through clathrin mediated endocytosis to basal epithelia from micro-abrasions.

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Human Papillomavirus (HPV)

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  1. Human Papillomavirus (HPV)

  2. Wed, Nov 21 2007 Tanjung Jaya, Indonesia

  3. The Virus • Papovaviridae • infect skin and mucous membrane • entry through clathrin mediated endocytosis to basal epithelia from micro-abrasions

  4. Epidemiology • modes of transmission is skin to skin, mucous membrane contact • perinatal transmission (rare) causing respiratory papillomatosis • 45% women at age 20-24, anyone sexually active is at risk

  5. HPV types • >100 subtypes, 30-40 STD • high-risk type HPV 16, 18, 35, 45 –leads to cervical, vulva, vaginalcancer and other genitalia cancer including in men • low-risk type HPV 6, 11 –causes genital warts • cutaneous HPV 1,2 –skin warts

  6. HPV type 16 and 18 cause nearly 70% of cases of cervical cancer • HPV type 6 and 11 cause approx. 90% of genital warts • Both 4 types cause 35-50% of all low grade cervical, vaginal and vulvar lesions

  7. Diagnosis • abnormal PAP smear • HPV DNA testing (problem- expensive, cannot distinguish active or latent) • acetic acid-warts more visible

  8. Treatment and Prevention • common skin and genital warts will regress spontaneously/ months/ years due to immune response • common warts also can be eliminated using lasers • vaccine Gardasil from Merck –approved June 2006 and Cervarix from GlaxoSmithKline –approved May 2007

  9. ‘trick’ body into thinking that there is HPV infection thus generates immune response • vaccine does not cure HPV, it prevents thus not suitable for infected patient, but not 100% prevention • best prevention = vaccine + PAP smear annually (depends)

  10. HPV in Malaysia • cervical cancer is 2nd most common cancer in women • Gardasil has been approved during October 2006 • MSD collaborate with OGSM to spearhead ‘Tell Someone’ campaign • small figures for those who undergoes PAP smear each year

  11. Reference • HPV http://alpha.montclair.edu/~Williamss4/diagnosis.htm http://udel.edu/~jlaverty/Human%20Papilloma%20Virus.html#Pathogenesis__Symptoms http://en.wikipedia.org/wiki/Human_papilloma_virus#HPV_testing • Cervical cancer is preventable 2007 http://www.redorbit.com/news/health/884330/cervical_cancer_is_preventable/index.html • ‘Tell Someone’ campaign in Malaysia http://www.msd-malaysia.com/content/corporate/about/news/2007/TellSomeone.html • Indonesia ‘Tree Man’ http://news.yahoo.com/s/nm/20071122/lf_nm_life/indonesia_tree_man_dc_1

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