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Genetically engineered crops allowed in the U.S. food supply. Genetically engineered crops allowed in the U.S. food supply. GM food production (1996 – 2004) (million Ha). total. Developed countries. Developing countries. GM food production (1996 – 2003) (million Ha).
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Genetically engineered crops allowed in the U.S. food supply
Genetically engineered crops allowed in the U.S. food supply
GM food production (1996 – 2004) (million Ha) total Developed countries Developing countries
GM food production (1996 – 2003) (million Ha) Soybean Corn Cotton Canola
Field after one round of application of Roundup herbicide Current Products • Transgenic Soybean • Roundup Ready • Resistant to Roundup Herbicide • Reduces the amount of herbicide applied to crops • Altered fatty-acid content • Changes the nutritional value
Glyphosateresistance(sugar beet, canola, soybean, chicory, corn)
Glufosinatresistance(sugar beet, canola, soybean, chicory, rice, corn)
Current Products • Canola • Herbicide resistant • Better for the environment • Altered fatty-acid composition • A value-added food
Transgenic tomato plants show resistance (left) while non-transformed plants are susceptible to cucumber mosaic virus under field conditions (right) Current Products • Tomato • Flavr Savr Tomato • Delayed softening • Consumers get a better tasting tomato • Failed • Virus resistant tomato • Resistant to pests • Decreases the amount of pesticide applied to crops
Wild-type corn showing infestation - Bt corn is resistant to this Current Products • Corn • Bt CornThe Monarch Butterfly debate: • A microbial gene added results in the crop being resistant to insects • Does it impact the Monarch Butterfly? • Well planned experiments are critical to the survival of biotechnology
Insect infestation on Bt (right) and non-Bt (left) cotton bolls Current Products • Cotton • Yes – clothes can be made from transgenic crops! • Bollgard cotton • Insect resistance • Lowers pesticide usage
Current Products • Papaya • Virus resistant • Restored the papaya industry in Hawaii • Reduced crop loss • Japan blocked imports of transgenic papaya
Golden rice and normal (white)www.fumento.com/ wsjbiotech.html Current Products • Golden Rice • Biotechnology’s poster child? • A true value added food • Vitamin A enriched rice prevents disease and blindness • Golden in colour
Golden Rice has not been developed by and for industry. • It fulfills an urgent need by complementing traditional interventions. • It presents a sustainable, cost-free solution, not requiring other resources. • It avoids the unfortunate negative side effects of the Green Revolution. • Industry does not benefit from it. • Those who benefit are the poor and disadvantaged. • It is given free of charge and restrictions to subsistence farmers. • It does not create any new dependencies. • It will be grown without any additional inputs. • It does not create advantages to rich landowners. • It can be resown every year from the saved harvest. • It does not reduce agricultural biodiversity. • It does not affect natural biodiversity. • There is, so far, no conceptual negative effect on the environment. • There is, so far, no conceivable risk to consumer health. • It was not possible to develop the trait with traditional methods, etc.
How a transgenic plant containing a vaccine is made Edible Vaccines • Plants producing vaccines could eliminate or simplify vaccine distribution problems in developing nations
Potatoes are one of many plants being used to produce vaccines Edible Vaccines • May have advantages over injected vaccines • Plants being studied include potato, banana, papaya, tomato, lettuce, carrot, rice, wheat, corn and soybean – Quite a salad!
Edible Vaccines • Tomato and potato plant can make antigens from Hepatitis B, E. Coli and V. cholerae • Feeding to test animals induces an immune response • Potatoes fed to human volunteers induced and immune response to an inactive form of the E. coli toxin
Other Cool Plant Biotech Products • Blue Carnations and Roses • Nature can not make these • Non-allergenic peanuts • Kids can take peanut butter sandwiches to school again! • Decaffeinated coffee • Less processing
How to constuct transgenic plants? • Microinjection • Viral vectors (e.g. lentiviruses, adenoviruses) (Univ. Pnnsylvania: Jesse Gelsinger)
How to constuct transgenic plants? • Agrobacterium tumefaciens • Cancerousgrowth in plant cells • (bacterial DNA) • Gene-gun • Gold or Wolframparticles (DNA-coated) • Particles must hit the cells • Cells must be able to repair the holes on cell membrane • DNA must intagrate into thegenome • Selection markers (e.g. Ab-resistance) • The transgenecontains: • Promotersequence, structural gene, stop sequence, marker-gene
GM Products: Benefits • Crops • Enhanced taste and quality • Reduced maturation time • Increased nutrients, yields, and stress tolerance • Improved resistance to disease, pests, and herbicides • New products and growing techniques • Animals • Increased resistance, productivity, hardiness, and feed efficiency • Better yields of meat, eggs, and milk • Improved animal health and diagnostic methods • Environment • "Friendly" bioherbicides and bioinsecticides • Conservation of soil, water, and energy • Bioprocessing for forestry products • Better natural waste management • More efficient processing • Society • Increased food security for growing populations
GM Products: Controversies • Safety • Potential human health impact: allergens, transfer of antibiotic resistance markers, unknown effects Potential environmental impact: unintended transfer of transgenes through cross-pollination, unknown effects on other organisms (e.g., soil microbes), and loss of flora and fauna biodiversity • Access and Intellectual Property • Domination of world food production by a few companies • Increasing dependence on Industralized nations by developing countries • Biopiracy—foreign exploitation of natural resources • Ethics • Violation of natural organisms' intrinsic values • Tampering with nature by mixing genes among species • Objections to consuming animal genes in plants and vice versa • Stress for animal • Labeling • Not mandatory in some countries (e.g., United States) • Mixing GM crops with non-GM confounds labeling attempts • Society • New advances may be skewed to interests of rich countries
Results of GM rice experiments in China GM non GM Costs of pesticides 31 jüan/ha 243 jüan/ha Amount of pesticides 2 kg/ha 21,2 kg/ha Work 0,73 day/ha 9,1 day/ha Yield 6364 kg/ha 6151 kg/ha Health related problems 0 3