1 / 23

Serbia - Italia Bilateral Cooperation

Serbia - Italia Bilateral Cooperation ACETYLCHOLINESTERASE INHIBITORY ACTIVITY OF THIO-AVAROL DERIVATIVES 25th and 26th June, 2012. Beograd. Pozzuoli - Napoli. The Sponges. Dysidea avara. Dr. Salvatore De Rosa Dirigente di Ricerca National Research Council of Italy

anthea
Download Presentation

Serbia - Italia Bilateral Cooperation

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Serbia - Italia Bilateral Cooperation ACETYLCHOLINESTERASE INHIBITORY ACTIVITY OF THIO-AVAROL DERIVATIVES 25th and 26th June, 2012

  2. Beograd

  3. Pozzuoli - Napoli

  4. The Sponges Dysidea avara

  5. Dr. Salvatore De Rosa Dirigente di Ricerca National Research Council of Italy Institute of Biomolecular Chemistry CNR-ICB E-mail: sderosa@icb.cnr.it

  6. Dr. Giuseppina Tommonaro Ricercatore National Research Council of Italy Institute of Biomolecular Chemistry CNR-ICB E-mail: gtommonaro@icb.cnr.it

  7. Mr. Carmine Iodice CollaboratoreTecnico ente di Ricerca National Research Council of Italy Institute of Biomolecular Chemistry CNR-ICB E-mail: ciodice@icb.cnr.it

  8. Avarolis a marine sesquiterpene hydroquinone possesing a rearanged drimane skeleton. Avarone is the quinone form of avarol.

  9. Avarol Avarone

  10. Avarolwas found to have anti-inflammatory antipsoriatic antioxidant antitumor antiplatelet analgesic anti-HIV activities.

  11. Of particular interest is acetylcholinesterase inhibitory activity of thio-avarol derivativeswith a carboxylic group in the molecule, such as avarol-3‘-thiobenzoate avarol-3‘–thiolactate avarol-4‘–thiolactate

  12. TLC bioautographic assay (white spot on a purple background) 1 μg Galanthamine was used a positive control.

  13. Galanthamine0.01 μg

  14. Dr. Pietro AmodeoI RicercatoreNational Research Council of ItalyInstitute of Biomolecular ChemistryCNR-ICBE-mail: pamodeo@icb.cnr.it

  15. Dr. Rosa Maria VitaleRicercatoreNational Research Council of ItalyInstitute of Biomolecular ChemistryCNR-ICBE-mail: rmvitale@icb.cnr.it

  16. Binding propertiesof avarol and its inhibitory derivativesto the enzymehave been characterising by computationalapproach.This research aims to design new avarol derivatives which better inhibitacetylcholinesterase.

  17. Serbia - ItaliaINSIEME NELLA SCIENZA,INSIEME NELLA VITA

More Related