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EUROPEAN EPILEPSY DATABASE. Aims Implementation of large, high-quality polymodal data from patients with epilepsy for the purpose of advanced analyses leading to an improved prediction of epileptic seizures Planned data content
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EUROPEAN EPILEPSY DATABASE • Aims • Implementation of large, high-quality polymodal data from patients with epilepsy for the purpose of advanced analyses leading to an improved prediction of epileptic seizures • Planned data content • 250 surface, 50 intracranial continuous long-term EEG data sets with annotations • Imaging data (3D MR data sets) • Structured metadata (clinical) • Derived features based on EEG analysis Grant 211713 EPILEPSIAE
Database: preparatory steps • Specific issues: • Safety of personal data • Pseudonymization of patient data • Deletion of data contents with identifying character • Ethical issues • Individual informed patient consent • Restrictions of access and use • Management of multimodal data • raw data (e.g. EEG/MRI data) • meta data (e.g. patient history, seizure counts, semiological characteristics, EEG annotations, electrode positions) • Multisite access to local databases of consortium members(data warehouse approach) • Multiple local databases • Procedures do assure identical data content Replicated European database Coimbra Freiburg Paris SQL Client interfaces Grant 211713 EPILEPSIAE
Clinical procedures Grant 211713 EPILEPSIAE Consortium consent on Inclusion criteria (Paris, 2008): Patients with focal and multifocal epilepsy Minimum duration of continuous EEG recordings: 96h (4 days) Minimal number of seizures: 5with aninterseizure interval of ≥ 3.5h Information on subclinical EEG events and sleep stages in the preictal period Appropriate electrode implantation for focus identification • Patient selection • Criteria for data quality • Standardized annotations(types and positioning of seizure-related markers: • Clinical seizure onset / first behavioural alteration • EEG seizure onset / first EEG change • Spikes • Subclinical events • Uniform nomenclature of EEG channels • EEG review • Metadata (types and inclusion form)
T1.1: clinical procedures Grant 211713 EPILEPSIAE Sleep staging EEG onset Early propagation EEG pattern morphology
Database client interfaces Grant 211713 EPILEPSIAE Coimbra Freiburg Paris
Database development Storage of sample values: • External binary files: space efficient & the way people are used to work • Inside database tables: flexible for querying • Database system: • Open source (PostgreSQL) vs. Oracle (commercial) • Decision for Oracle to allow the storage of the samples inside the database Replicated vs. distributed database • Local datatbase at every site, replicated content • Not a single distributed database because of immense data traffic • Estimation of data volume: > 50Tb Grant 211713 EPILEPSIAE
Present status The database is open for collaboration with US-databases www.epilepsiae.eu