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Advanced Epilepsy Database for Seizure Prediction

The European Epilepsy Database aims to implement large-scale and high-quality polymodal data from epilepsy patients for advanced analyses leading to improved seizure prediction. The database includes EEG data sets, imaging data, and structured clinical metadata. With a focus on data safety, ethical issues, and patient consent, the database ensures strict access restrictions and quality control procedures. Consortium members in Coimbra, Freiburg, and Paris contribute to the replicated database development, offering client interfaces and detailed clinical procedures. Interested parties can collaborate with the database via www.epilepsiae.eu.

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Advanced Epilepsy Database for Seizure Prediction

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  1. EUROPEAN EPILEPSY DATABASE • Aims • Implementation of large, high-quality polymodal data from patients with epilepsy for the purpose of advanced analyses leading to an improved prediction of epileptic seizures • Planned data content • 250 surface, 50 intracranial continuous long-term EEG data sets with annotations • Imaging data (3D MR data sets) • Structured metadata (clinical) • Derived features based on EEG analysis Grant 211713 EPILEPSIAE

  2. Database: preparatory steps • Specific issues: • Safety of personal data • Pseudonymization of patient data • Deletion of data contents with identifying character • Ethical issues • Individual informed patient consent • Restrictions of access and use • Management of multimodal data • raw data (e.g. EEG/MRI data) • meta data (e.g. patient history, seizure counts, semiological characteristics, EEG annotations, electrode positions) • Multisite access to local databases of consortium members(data warehouse approach) • Multiple local databases • Procedures do assure identical data content Replicated European database Coimbra Freiburg Paris SQL Client interfaces Grant 211713 EPILEPSIAE

  3. Clinical procedures Grant 211713 EPILEPSIAE Consortium consent on Inclusion criteria (Paris, 2008): Patients with focal and multifocal epilepsy Minimum duration of continuous EEG recordings: 96h (4 days) Minimal number of seizures: 5with aninterseizure interval of ≥ 3.5h Information on subclinical EEG events and sleep stages in the preictal period Appropriate electrode implantation for focus identification • Patient selection • Criteria for data quality • Standardized annotations(types and positioning of seizure-related markers: • Clinical seizure onset / first behavioural alteration • EEG seizure onset / first EEG change • Spikes • Subclinical events • Uniform nomenclature of EEG channels • EEG review • Metadata (types and inclusion form)

  4. T1.1: clinical procedures Grant 211713 EPILEPSIAE Sleep staging EEG onset Early propagation EEG pattern morphology

  5. Database client interfaces Grant 211713 EPILEPSIAE Coimbra Freiburg Paris

  6. Database development Storage of sample values: • External binary files: space efficient & the way people are used to work • Inside database tables: flexible for querying • Database system: • Open source (PostgreSQL) vs. Oracle (commercial) • Decision for Oracle to allow the storage of the samples inside the database Replicated vs. distributed database • Local datatbase at every site, replicated content • Not a single distributed database because of immense data traffic • Estimation of data volume: > 50Tb Grant 211713 EPILEPSIAE

  7. Present status The database is open for collaboration with US-databases www.epilepsiae.eu

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