Hydroxypinacolone Retinoate Powder What is it and Why Do We Need It

1. Hydroxypinacolone Retinoate Powder: What is it and Why Do We Need It? Human skin is the largest organ of the body and it is the organ that is most exposed to external stressors like pollution, UV rays, and environmental toxins. Moreover, the skin is affected by genetics and several other internal, physiological factors. All of these take a toll on the texture and appearance of the skin, resulting in photodamage to the skin or aging of the skin out of proportion with physiologic age. Some of the other potential problems of the skin, as a result of multiple internal and external factors, include, but are not limited to acne, hyperpigmentation, blemishes, and enlarged pores. These dermatological issues are of huge concern to women worldwide, with most women spending huge amounts of their incomes on skincare products to improve the appearance of their skin. Hyaluronic acid, Vitamin C, collagen, and Retinoids are considered the main ingredients for hydration, repair, and anti-aging features of skincare products, respectively. Retinol is a Vitamin A derivative, that in certain forms, is medically prescribed to treat acne. However, retinoids are not stable and even isotretinoin, the form medically used for the treatment of acne, has various clinically significant side effects associated with it. Due to this, there has always been different research and studies performed into newer forms of retinoid that may be more stable and have fewer side effects. These studies led to the discovery of Hydroxypinacolone Retinoate. Hydroxypinacolone Retinoate is a relatively new retinoid that has antimicrobial and anti aging properties, making it highly famous in the world of cosmetics, in a short duration of time. 1. What is Hydroxypinacolone Retinoate Powder? Hydroxypinacolone Retinoate Powder is the ester of tretinoin, widely available in the form of a yellow HPR powder, wholesale or retail. Before detailing the features of Hydroxypinacolone Retinoate, it is important to differentiate between retinol, tretinoin, and retinol esters because although www.apicdmo.com JINAN APICDMO BIOTECHNOLOGY CO., LIMITED Tel: +8613682461609 Email: emily@apicdmo.com

2. they are all derivatives of vitamin A, their uses, actions, and benefits differ significantly. Tretinoin is a concentrated all-trans retinoic acid that is widely prescribed by dermatologists to treat moderate to severe acne. It is a retinoid that is only available by prescription and cannot be bought over the counter. Retinol, on the other hand, is a common ingredient in most anti-aging and acne-managing creams and topical agents. Retinol is also retinoic acid however, it is not packaged as such. In fact, retinol must undergo chemical changes, once applied, with the help of enzymes in the skin to convert into retinoic acid. Tretinoin and Retinol are both retinoids, which is a class of Vitamin A compounds, both natural and synthetic. The use of retinoids gained traction in the late 1980s and since then, their use has been scientifically backed and supported with Tretinoin receiving FDA approval as a drug for the management of acne vulgaris. Hydroxypinacolone Retinoate is a newly discovered retinoid that is believed to be more stable and effective in managing a wide range of skin issues such as acne, hyperpigmentation, blemishes, and so on. Also known as granactive retinoid, this specific retinoid is an oxidized retinoid that is less likely to cause skin irritation. The main side effect of retinoid use is the high risk of skin irritation and eczema-like symptoms that occur in most people using either tretinoin or retinol. The use of Hydroxypinacolone Retinoate Powder has been on a rise recently mostly because of a clear lack of skin irritation as a potential side effect. However, it is also being widely used because of its small molecular size which keeps it well dispersed in topical agents, creams, and essence before it is applied to the skin. This dispersion is essential for the stability of the compound which, in turn, is needed for the best results. Moreover, this small size of the oxidized retinoid is beneficial in the deep penetration of the compound into the skin, helping heal the skin and reverse the photodamage from the inside. Hydroxypinacolone Retinoate Powder is a yellow powder, sold wholesale directly from Hydroxypinacolone Retinoate Powder manufacturers to different cosmetic and skin care manufacturers, for the production of acne-treating, anti-aging topical agents and essences with HPR as the key ingredient. Hydroxypinacolone Retinoate Powder factory manufactures this agent with utmost precision ensuring the high quality and safety of the final product. www.apicdmo.com JINAN APICDMO BIOTECHNOLOGY CO., LIMITED Tel: +8613682461609 Email: emily@apicdmo.com

3. 2. Mechanism of Action of Hydroxypinacolone Retinoate Powder Hydroxypinacolone Retinoate Powder directly after being applied binds to the receptors, without requiring conversion into retinoic acid like retinol. It promotes thickness of the skin, renewal of skin cell types, and hydration of the skin to repair it and reduce the risk of further damage to the skin. At the same time, it also increases collagen and elastin levels which further remove visible signs of aging from the skin. There are many benefits that are responsible for its fame and wide use in the cosmetic industry, and these are the only benefits that are yet known. Given that it was only recently discovered, there is a high probability that there are quite a few benefits that have yet not been discovered. 3. Hydroxypinacolone Retinoate PowderApplications (1) Anti-Behavior Products Promote collagen synthesis in the dermis and prevent excessive choleagen degradation. Improvements to fine lines can be seen within a week. (2) Skin Whitening Products Demonstrate tires, promote metabolism, and accelerate the disappearance of melanin. Literature shows that blending with VC is just as effective in treating acne scars. (3) Acne extract products Not only does it reduce acne, it can also reduce oil production and lighter pigeons left over from acne. (4) Sunscreen Products Demonstrates the enhancement of UV-induced MMP activity, protects elastin and dermal collagen, and heals wrinkles and fine lines caused by UV radiation. (5) Repairs and Maintenance Products www.apicdmo.com JINAN APICDMO BIOTECHNOLOGY CO., LIMITED Tel: +8613682461609 Email: emily@apicdmo.com

4. Promote the synthesis of hylaluronic acid in the body, reduce skin TEWL, promote the activity of keratinocytes, increase epidermis thickness, and make the epidermis stronger. 4. Benefits of Hydroxypinacolone Retinoate Powder Hydroxypinacolone Retinoate Powder is a slow-acting anti-aging compound that has a small molecular size. It is the key ingredient of several skincare products advertised as anti-aging, anti-blemish, and anti-acne treatments. Some of the main benefits of Hydroxypinacolone Retinoate Powder include: · No serious side effects Hydroxypinacolone Retinoate Powder is safer to use than other retinoids, especially retinol, as it has a relatively large molecular weight when compared to retinol which prevents rapid dispersion of the topical agents with HPR powder. Slow absorption of the active ingredient allows the skin to adapt to the effects of HPR powder and prevents sudden changes in the skin which are responsible for the presence of irritated skin. HPR powder is considered safe to use also because of an enhanced transdermal rate of the topical agents and essences. In fact, skin care products with HPR powder as their active ingredient are recommended to be used around the eyes to treat dark circles and sunken eyes. This feature of this specific compound is unique to it as other retinoids can be quite irritating for the sensitive, thin skin around the eyes. · Deeper penetration than Retinol or Tretinoin As mentioned above, Hydroxypinacolone Retinoate Powder has a slower rate of spread and absorption by the skin which is the main reason behind the safety of this compound. The compound’s molecular size allows it to also be stable and disperse evenly. With a relatively small molecular weight, it can easily and effectively go through the different layers of the skin, reaching all the way to the bottom to ensure maximal benefits. www.apicdmo.com JINAN APICDMO BIOTECHNOLOGY CO., LIMITED Tel: +8613682461609 Email: emily@apicdmo.com

5. HPR powder, after penetrating into the deeper layers of the skin, causes changes at the cellular level to improve the texture, appearance, and pigmentation of the skin, deep from inside. · Anti-aging properties One of the main benefits of Hydroxypinacolone Retinoate Powder is its anti-aging properties that most factories with HPR powder for sale claim to knock several years off of one’s face. Aging produces visible changes in the appearance of the skin, starting off with fine lines and wrinkles as a result of decreased levels of collagen. Collagen is responsible for the structural stability and integrity of the skin, however, as one ages, the collagen levels in the skin begin to decrease resulting in structural destruction of the skin. As time passes, collagen breakdown also results in decreased elastin which is yet another important compound found in the skin. It is responsible for maintaining appropriate elasticity of the skin, and when reduced, results in saggy and loose skin that gives the appearance of jowls. Sagginess of the skin of the neck and facial wrinkles are the main signs of aging of the skin, and they are the result of collagen and elastin deficiency. Several studies have shown that Hydroxypinacolone Retinoate Powder is able to affect collagen synthesis in the dermis layer of the skin. Moreover, HPR powder also prevents the breakdown of collagen from occurring so that not only do users benefit from the reversal of signs of aging, but they also benefit from prevention of these signs from occurring again. Effects of aging may be exaggerated by prolonged exposure to UV rays which break down dermal collagen and elastin, resulting in photodamaged and aged skin disproportionate to the actual age. The use of Hydroxypinacolone Retinoate Powder is believed to inhibit the activity of MMPs, which is increased after exposure to UV rays and is necessary for photodamage to occur. This helps combat the effects of UV rays by allowing HPR powder to reverse and maintain the anti-aging features. · Skin Whitening properties Hyperpigmentation is yet another cosmetic issue that affects women all over the world. White spots or light spots are issues with hypopigmentation that can occur as well, although not as commonly. During pregnancy, women develop a www.apicdmo.com JINAN APICDMO BIOTECHNOLOGY CO., LIMITED Tel: +8613682461609 Email: emily@apicdmo.com

6. condition known as melasma which is hyperpigmentation of the skin during most of the pregnancy, if not entire, as a result of hormonal changes. All these hyperpigmentation disorders have been hard to treat in the past, especially melasma as tretinoin and retinol are not recommended to be used amongst pregnant and breastfeeding women. Hydroxypinacolone Retinoate Powder inhibits the activity of tyrosinase, an enzyme necessary for the breakdown of the amino acid, tyrosine, which is crucial for the synthesis of the human body’s pigment, namely melanin. Moreover, this compound is effective in treating melasma as it enhances the clearance or removal of melanin from the skin that increases as a result of hormonal changes during pregnancy. OVerall, HPR powder increases the breakdown of melanin while also inhibiting the synthesis of the pigment to fight the hyperpigmentation problem in many people. · Repair and hydration of the skin One of the main factors that result in deterioration of skin’s texture and appearance is lack of hydration which, to an extent, affects the skin’s ability to repair itself and combat the effects of external and internal irritants. The use of Hydroxypinacolone Retinoate Powder is believed to increase hyaluronic acid synthesis in the skin, which is the main compound, found in the extracellular matrix of the skin, responsible for proper hydration and rejuvenation of the skin from the inside. Simultaneously, HPR powder reduces the water lost via the Transepidermal Water Loss or TEWL to maintain proper hydration of the skin. Moreover, the use of HPR powder is associated with increased thickness of the epidermal or top layer of the skin. This is important as it improves the skin’s barrier, preventing any further damage to the skin. · Treatment and management of acne One of the reasons for acne is sebum overproduction, resulting in clogged pores and inflammation, appearing as pimples and acne. Hydroxypinacolone Retinoate Powder reduces sebum overproduction in the skin and it has www.apicdmo.com JINAN APICDMO BIOTECHNOLOGY CO., LIMITED Tel: +8613682461609 Email: emily@apicdmo.com

7. antimicrobial properties which inhibit the colonization of P.acnes bacteria in the skin as it can cause severe cases of acne. As HPR powder is able to whiten the skin, it also helps reduce the pigmentation seen along with acne scars. 5. Side Effects of Hydroxypinacolone Retinoate Powder Given that Hydroxypinacolone Retinoate Powder was only discovered recently and is still being studied to know more of its benefits and effects, not much is known about the potential side effects of the HPR powder. However, it belongs to the ‘royal family’ of skincare products’ ingredients as it produces the same, if not better, effects as other retinoids without producing skin irritation as a side-effect, unlike the others. 6. How to Buy Hydroxypinacolone Retinoate Powder? To buy HPR Powder, it is best to directly contact the Hydroxypinacolone Retinoate Powder factory and buy HPR wholesale. This yellow powder must be bought from factories that manufacture it using safety guidelines and store it such that it does not react with other compounds or spoil before being sold in bulk. It should be stored in a cold, ventilated warehouse or storage space with the optimal temperature being between 36 and 37 degrees, never more. Welcome to Order Hydroxypinacolone Retinoate Bulk Powder from APICDMO! Reference [1] Truchuelo, Maria Teresa; Jiménez, Natalia; Jaén, Pedro (2014). “Assessment of the efficacy and tolerance of a new combination of retinoids and depigmenting agents in the treatment of melasma”. Journal of Cosmetic Dermatology 13 (4): 261–268. doi:10.1111/jocd.12110. www.apicdmo.com JINAN APICDMO BIOTECHNOLOGY CO., LIMITED Tel: +8613682461609 Email: emily@apicdmo.com

8. [2] S. Veraldi, M. Barbareschi, E. Guanziroli; et al (2015-4). “Treatment of mild to moderate acne with a fixed combination of hydroxypinacolone retinoate, retinol glycospheres and papain glycospheres”. Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia 150 (2): 143–147. PMID 25876142. [3] Sarah Vickery (2018 年 5 月 17 日). “The Estée Lauder Companies showcases robust research at 2018 IID Meeting”. EurekAlert!. 2019 年 6 月 21。 [4] Katie Rodan, Kathy Fields, George Majewski, Timothy Falla (2016-12). “Skincare Bootcamp: The Evolving Role of Skincare”. Plastic and reconstructive surgery. Global open 4 (12 Suppl Anatomy and Safety in Cosmetic Medicine: Cosmetic Bootcamp): e1152. doi:10.1097/GOX.0000000000001152. PMC: 5172479. PMID 28018771 [5] Nora Ruth, Thomas Mammone (2018). “Antiaging effects of retinoid hydroxypinacolone retinoate on skin models”. Journal of the American Academy of Dermatology 79 (3): AB44. doi:10.1016/j.jaad.2018.05.215. [6] Treatment of mild to moderate acne with a fixed combination of hydroxypinacolone retinoate, retinol glycospheres and papain glycospheres PMID 25876142; Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia 2015 Apr; 150(2):143-7 www.apicdmo.com JINAN APICDMO BIOTECHNOLOGY CO., LIMITED Tel: +8613682461609 Email: emily@apicdmo.com