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MRC Lifecourse Epidemiology Unit Cyrus Cooper, Director

MRC Lifecourse Epidemiology Unit Cyrus Cooper, Director. MRC LEU ; Southampton 2013. MRC Lifecourse Epidemiology Unit 2010-2015. . Fetus & Infant. Child. Aetiology. . Research focus. Research focus. Mechanisms. Intervention. . Adult. Lifecourse epidemiology. Programmes.

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MRC Lifecourse Epidemiology Unit Cyrus Cooper, Director

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  1. MRC Lifecourse Epidemiology Unit Cyrus Cooper, Director MRC LEU; Southampton 2013

  2. MRC Lifecourse Epidemiology Unit 2010-2015  Fetus & Infant Child Aetiology  Research focus Research focus Mechanisms Intervention  Adult Lifecourse epidemiology Programmes Programmes Work and Health Musculoskeletal ageing Nutrition, development, and lifelong health • Scientific Mission • To delineate: • The environmental causes throughout the lifecourse of •  chronic musculoskeletal disorders •  obesity, type 2 diabetes and cardiovascular disease • Population-based and high-risk preventive strategies against these disorders Mission Mission

  3. Young women’s diet, body composition, physical activity, education and lifestyle before and during pregnancy Developmental plastic responses Epigenetic processes Infant body composition & development Weight gain and catch-up growth Infant feeding and illnesses MECHANISMS BEHAVIOURS Childhood body composition and development Childhood diet, physical activity, lifestyle and education Work, lifestyle and health behaviours in adulthood Vulnerability to chronic disease in later life Retirement and ageing Lifecourse determinants of health and disease Gluckman, Hanson, Cooper et al New Engl J Med 2008; 359: 61-73 Harvey N, Cooper C BMJ 2012; 345: e4695

  4. Lifecourse strategy for disease prevention No intervention Late intervention impactful for vulnerable groups Chronic NCD risk Adulthood Late intervention Childhood Earlier intervention improves functional capacity & responses to new challenges Mother & infant Early intervention Life course Plasticity Inadequate response to new challenges Gluckman, Hanson, Cooper et al New Engl J Med 2008; 359: 61-73 Hanson M , Godfrey K et al Prog Biophys Molec Biol 2011; 106: 272-280

  5. Scientific Programmes • Lifecourse determinants of bone and joint disease • Sarcopenia, physical frailty and clinical care in older people • Nutrition, development and lifelong health (Developing/transitioning populations) • Nutrition, development and lifelong health (Developed populations) • Work and Health

  6. Scientific achievements Maternal vitamin D insufficiency and childhood bone mineral accrual Developmental origins of sarcopenia and cognitive function Maternal micronutrient status, birthweight and childhood adiposity Self-efficacy and control as determinants of food choice among young women Health beliefs, somatising tendency, physical exposures and musculoskeletal disability

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