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2014 年 4 月 研究生读书报告

2014 年 4 月 研究生读书报告. 王凯 硕 士研究生 临 床检验诊断学. Seminars In Cancer Biology. Cancer Discovery. A review of the current understanding and clinical utility of miRNAs in esophageal cancer

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2014 年 4 月 研究生读书报告

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  1. 2014年4月研究生读书报告 王凯 硕士研究生 临床检验诊断学

  2. Seminars In Cancer Biology Cancer Discovery A review of the current understanding and clinical utility of miRNAs in esophageal cancer Comparative Genomic Analysis of Esophageal Adenocarcinoma and Squamous Cell Carcinoma

  3. miRNAs In Esophageal Cancer • Genomic Analysis of Esophageal Cancer • 1 • 2 • 4 • 3 • Conclusion • Sparkleof Inspiration

  4. Four miRNAs (mi-R-25, -99a, -133a and -133b) showed good potential as diagnostic markers and interestingly five (mi-R-21, -27b, -126, - 143 and -145) appeared to be useful both as diagnostic and prognostic/predictive markers.

  5. Summary of studies looking at miRNA expression in tumor tissues and non-tumor tissues

  6. Summary of miRNAs identified to have a role in determining prognosis

  7. Summary of key miRNAs identified as having a potential role in the diagnosis and/or prognosis of oesophageal cancer

  8. miRNAs In Esophageal Cancer • Genomic Analysis of Esophageal Cancer • 1 • 2 • 4 • 3 • Conclusion • Sparkleof Inspiration

  9. 12 • ESCC • 23 fresh-frozen primary tumors • 11 • EAC NOTCH1 TP53 A:T>C:G C:G>G:C EAC ESCC Tumor Tissue

  10. miRNAs In Esophageal Cancer • Genomic Analysis of Esophageal Cancer • 1 • 2 • 4 • 3 • Conclusion • Sparkleof Inspiration

  11. miRNAs In Esophageal Cancer • Genomic Analysis of Esophageal Cancer • 1 • 2 • 4 • 3 • Conclusion • Sparkleof Inspiration

  12. Thank You

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