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How Animals Move. Chapter 21. Pumping Up Muscles. Androstenedione Intermediate in testosterone and estrogen synthesis pathways Taken as dietary supplement Doesn’t help add muscle Does have negative side effects. Pumping Up Muscles. Creatine phosphate Short chain of amino acids
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How Animals Move Chapter 21
Pumping Up Muscles • Androstenedione • Intermediate in testosterone and estrogen synthesis pathways • Taken as dietary supplement • Doesn’t help add muscle • Does have negative side effects
Pumping Up Muscles • Creatine phosphate • Short chain of amino acids • Donates phosphate to ATP when muscles need quick energy • Does enhance performance in sports that require short bursts of energy • Long-term effects unknown
3 Types of Skeletons feed me! • Hydrostatic skeleton • Exoskeleton resting
3 Types of Skeletons 3. Endoskeleton (vertebrates) Generalized mammal pelvic girdle pectoral girdle
Skull bones Pectoral girdle and upper limb bones a d CRANIAL BONES FACIAL BONES CLAVICLE SCAPULA Rib Cage b STERNUM HUMERUS RADIUS RIBS CARPALS Vertebral Column c ULNA PHALANGES VERTEBRAE METACARPALS INTERVERTEBRAL DISKS Pelvic girdle and lower limb bones e PELVIC GIRDLE FEMUR PATELLA TIBIA ligament bridging a knee joint, side view, midsection FIBULA TARSALS METATARSALS PHALANGES Fig. 21-3, p.351
Functions of Bones • Interact with muscle to enable movement • Support and anchor muscles • Enclose and protect internal organs • Store calcium and phosphorus • Produce blood cells
Long Bone Structure • Compact bone • Spongy bone • Central cavity contains yellow marrow nutrient canal central cavity (contains yellow marrow) compact bone tissue spongy bone tissue
Compact Bone Structure • Compact bone consists of many dense, cylindrical layers surrounding canals cylindrical layers blood vessel outer layer of dense connective tissue spongy bonetissue compact bone tissue
Bone Marrow • Yellow marrow • Fills the cavities of adult long bones • Is largely fat • Red marrow • Occurs in spongy bone of some bones • Produces blood cells
Bone Mass • In adults, bone building and bone breakdown continue constantly • Osteoblast secretions form bone • Osteoclasts enzymes degrade bone • Adding and removing minerals adjusts bone strength and helps maintain blood calcium levels
Bone Density • Exercise can increase bone density • Osteoporosis: Decrease in bone density • May occur when the action of osteoclasts outpaces that of osteoblasts • May also occur as a result of inability to absorb calcium
Where Bones Meet • Joints: Areas of contact or near contact between bones • Ligaments: Straps of connective tissue at joints • Arthritis: Joint damage or inflammation • Osteoarthritis • Rheumatoid arthritis
Skeletal Muscle • Bundles of muscle fibers • Tendons attach muscles to bone • Lever system • Opposing muscle groups biceps triceps
Skeletal Muscle Contraction • A muscle is made up of bundles of muscle fibers • Muscle fiber contains cross-banded myofibrils myofibril
Sarcomere Myofibril is made up of thick and thin filaments arranged in sarcomeres sarcomere sarcomere sarcomere sarcomere Z band Z band Z band
Muscle Microfilaments Thin filaments • Two actin strands twisted together • Globular proteins • Parallel with myofibril • Thick filaments • Myosin • Motor protein • Tail and double head
Sliding-Filament Model • Myosin heads attach to actin filaments • Myosin heads tilt toward sarcomere center, pulling actin with them
Sliding-Filament Model When actin filaments are pulled inward, toward sarcomere center, sarcomere shortens Filaments themselves do not shorten
Contraction Requires Calcium • Skeletal muscles contract in response to signals from motor neurons • Signals release calcium from sarcoplasmic reticulum • Calcium allows actin and myosin to bridge
Contraction Requires Energy • Muscle cells require huge amounts of ATP energy to power contraction • Cells store only small amounts of ATP • Three pathways supply ATP to power muscle contraction
ATP for Contraction ADP + Pi pathway 1 dephosphorylation creatine phosphate relaxation contraction creatine pathway 2 aerobic respiration pathway 3 glycolysis alone glucose from bloodstream and from glycogen break down in cells oxygen
Motor Unit • One neuron and all muscle fibers it controls • When a motor neuron is stimulated, all fibers in muscle unit contract simultaneously, producing muscle twitch • Rapid, repeated stimulus of motor unit produces tetanus
peak Twitch and Tetanus relaxation stimulus contraction starts time number of stimuli per second number of stimuli per second tetanic contraction twitch repeated stimulation
Muscle Tension • Mechanical force exerted on an object by a contracting muscle • For a muscle to shorten, muscle tension must exceed the load that opposes it • Load may be the weight of an object or pull of gravity on muscle
Two Types of Contraction Muscle contracts but can’t shorten Muscle shortens as it contracts Isotonic contraction: Load is less than muscle’s peak capacity Isometric contraction: Load is greater than muscle’s peak capacity
Infection and Motor Neurons • Bacterial toxins block motor neuron control • Clostridium botulinum, botulism • Clostridium tetani, tetanus
Muscle Fatigue • Inability to maintain muscle tension • Glycogen is depleted after a period of tetanic contraction • Requires recovery time
Muscular Dystrophies • Genetic disorders in which muscles weaken and degenerate • Duchenne muscular dystrophy • Defective protein in muscle plasma membrane prevents normal binding of actin filaments to Z band • Myotonic muscular dystrophy
Exercise • Aerobic • Long duration, low intensity • Increases number of mitochondria, number of blood capillaries to all skeletal muscle • Strength training • Intense, short duration • Makes fast-acting muscles form more myofibrils and enzymes for glycolysis
Aging • Muscles shrink • Number of muscle fibers decreases • Slower healing time • Aerobic exercise improves fitness and memory