1 / 24

Immunology Overview

0. Immunology Overview. Non-specific, rapid Physical, Chemical Barriers Complex Biochemical Mechanisms Fever Inflammation Complement Toll and Nod. Antigen specific and initially slow Memory Lymphocytes Humoral and Cellular Exquisitely Specific Recognition molecules. 0.

arleen
Download Presentation

Immunology Overview

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. 0 Immunology Overview

  2. Non-specific, rapid Physical, Chemical Barriers Complex Biochemical Mechanisms Fever Inflammation Complement Toll and Nod Antigen specific and initially slow Memory Lymphocytes Humoral and Cellular Exquisitely Specific Recognition molecules 0 Innate vs Acquired Immunity

  3. 0 Eukaryote Innate Immunity

  4. 0 Cells of the Immune System

  5. 0 The Immune System

  6. 0 The Clonal Selection Theory

  7. 0 Primary vs Secondary Response

  8. 0 Antigenicity • Antigen - any molecule that binds to and activates the specific receptors of lymphocytes • Immunogenicity • Specificity • Epitopes • Some molecules (haptens) have specificity but no immunogenicity -- these need a carrier • Digoxigenin • peptides

  9. 0 DIG - KLH

  10. 0 Requirements for Immunogenicity • Foreignness • High Molecular Weight • Chemical Complexity • Degradability • Host Factors • Genetics • Route of encounter / Adjuvants

  11. 0 Protein Structure

  12. 0 Myoglobin Epitopes

  13. 0 Lysozyme Epitopes

  14. 0 Compare Epitope Structures

  15. 0 Antibody Structure

  16. 0 The 5 Antibody Classes

  17. 0 Mammalian Antibody Isotypes

  18. 0 The Immunoglobulin Superfamily

  19. 0 The Central Dogma

  20. 0 and GOD said, “Let there be light chains!”

  21. 0 Light chain exon rearrangement

  22. 0 “and let there be heavy chains!”

  23. 0 The Clonal Selection Theory

  24. 0 Monoclonal Antibodies

More Related