IMMUNOLOGY

1. IMMUNOLOGY Doc. dr Dušan Popadić Doc. dr Miloš Marković Ass. dr Emina Savić Prof. dr Vera Pravica imunologija@med.bg.ac.rs Tel. 3643-236 Facebook: Antitelija Limfocitic

2. Welcome to Immunology Course

3. Advice • for successful learning • and passing the exam

4. Immunology Course (40 hours) Lectures (12 hrs) Practice (SeminarsandLabs 28 hrs)

5. Seminars and Labsduring first 14 weeks Lecturesduring first 12weeks Seminars,Labsand Lectures are integral parts of the course Student are allowed to be absent on seminar or lab twice during the semester

6. In addition to these 40 hrs to prepare the exam you will need 60 hours of effective work Preparation of colloquium and final exam (45 hrs) Preparation for lectures and practice (15 hrs) Lectures (12 hrs) Practise (seminars and labs 28 hrs)

7. References • Basic Immunology: Functions andDisordersof the Immune System • Authors: Abbas AK, Lichtman AH. • Publisher:Elsevier • 3rd edition updated, 2011 .ppt presentationsand authorised supplementary material (available on web site)

8. Continuous assessment activities on the course (seminars, labs and lectures) – through activity points presence on lectures noted separately colloquium – partial, after every 4 weeks (5th, 9th and 13th week)

9. Colloquium Test (multiple choice – 1 correct answer out of 4) It consists of 30 questions in total (divided into 3 mini tests) 1 point for each answer, max 30 points 15 minutes per mini test - first: in the 5th week - second: in the 9th week - third: in the 13th week Final exam Final test with combined multiple choice and short answer questions Threshold for a pass is 31 points, max 60 points

10. Final mark in Immunology Final exam mark (60%) Colloquium score (30%) Activity on seminars and labs (7%) Regularity of course attendance (3%)

11. Final mark in Microbiology and Immunology Final mark in Immunology (25%) Februarysession→ Final mark in Microbiology (75%) June session→ Pass in Immunology is a condition for starting the exam in Microbiology

12. Introduction to immune system • Innate and adaptive immunity • Types of adaptive immunity • Properties and phases of adaptive immune response • Central and peripheral lymphoid organs • Lymphocyte recirculation

13. ADAPTIVE (Aquired) INNATE (Natural) (Native) IMMUNITY

14. Principle mechanisms of innate and adaptive immunity

15. Principle mechanisms of innate and adaptive immunity

16. The most important cells of the immune system

17. Chain of events in infection

18. Pathogen(s) enter(s) tissue

19. Pathogen(s) enter(s) tissue

20. Pathogen(s) enter(s) tissue

21. Macrophages recognize (and eliminate) pathogens

22. Macrophages recognize (and eliminate) pathogens

23. Macrophages recognize (and eliminate) pathogens

24. Inflammation is induced and PMNs attracted

25. Inflammation is induced and PMNs attracted

26. Antigen-presenting cells (APCs) capture antigen(s)

27. Antigen-presenting cells (APCs) capture antigen(s)

28. APCs migrate to draining lymph node

29. APCs migrate to draining lymph node

30. APCs migrate to draining lymph node

31. APCs migrate to draining lymph node

32. APCs migrate to draining lymph node

33. APCs migrate to draining lymph node

34. APCs migrate to draining lymph node

35. APCs migrate to draining lymph node

36. APCs migrate to draining lymph node

37. T cells are activated by APCs

38. T cells are activated by APCs

39. T cells are activated by APCs

40. B cell are activated (helped by T cells)

41. B cell are activated (helped by T cells)

42. B cell are activated (helped by T cells)

43. Activated B cells (plasma cells) produce antibodies (Abs)

44. Activated B cells (plasma cells) produce antibodies (Abs)

45. Activated B cells (plasma cells) produce antibodies (Abs)

46. Activated B cells (plasma cells) produce antibodies (Abs)

47. Activated T cellsandAbsleave lymph node...

48. ... enter blood stream and...

49. ... enter blood stream and...

50. ... migrate to site of infection