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The Role of Immune Nutrients in Aging : The Myths and the Facts

The Role of Immune Nutrients in Aging : The Myths and the Facts. Ishak Özel Tekin Bulent Evecit University School of Medicine Department of Immunology ZONGULDAK TURKEY. Lamp Jinn the Immunologist. Ilya Ilyich Mechnikov Nobel Prize 1908. Atherosclerosis. Phagocytosis.

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The Role of Immune Nutrients in Aging : The Myths and the Facts

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  1. The Role of ImmuneNutrients in Aging:TheMythsandtheFacts Ishak Özel Tekin BulentEvecitUniversity School of Medicine Department of Immunology ZONGULDAK TURKEY

  2. LampJinntheImmunologist

  3. IlyaIlyichMechnikov Nobel Prize 1908

  4. Atherosclerosis Phagocytosis METCHNIKOFF QUARTET Senescence Death

  5. Thefirstdice is thrownbeforethebirth. Ourchoiseswilldeterminetheother.

  6. Life Expectancy • Heredity • Disease Processes • Medical Treatment • Lifestyle Choices • Nutrition

  7. ImmuneSignature DERYA UNUTMAZ NYU

  8. Middle Aged Young Infant

  9. The Telomere Hypothesis of Aging A.M. Olovnikov, 1996 • Telomeres are sequences of nucleic acid • End pieces of DNA (the tail of DNA) • Whenthecellsdividetelomeres shorten • Once the telomeres become too short, cell division slows and finally ceases and the cell will die TTAGGG …TTAGGGTTAGGGTTAGGGTTAGGGTTAGGGTTAGGGTTAGGGTTAGGGTTAGGGTTAGGGTTAGGGTTAGGG TTAGGGTTAGGGTTAGGGTTAGGGTTAGGGTTAGGGTTAGGGTTAGGGTTAGGGTTAGGG TTAGGGTTAGGGTTAGGGTTAGGGTTAGGGTTAGGGTTAGGGTTAGGG TTAGGGTTAGGGTTAGGGTTAGGGTTAGGGTTAGGG TTAGGGTTAGGGTTAGGGTTAGGG TTAGGGTTAGGGTTAGGG TTAGGGTTAGGG TTAGGG

  10. FISH

  11. RTL(RelativeTelomerLength) Flow FISH

  12. Immunosenescence • Lifelong antigenic stress • Filling of the immunological space • Accumulation of effectorTcellsand memory cells • Reduction of naïve T cells • Deterioration of clonotypical immunity • Up-regulation of the innate Immunesystem

  13. Immunosenescence

  14. The Dietary Intake of Wheat and other Cereal Grains and Their Role in Inflammation Karin de Punder and Leo Pruimboom Nutrients2013, 5, 771-787

  15. Immunonutrients • Macronutrients -Glutamine - Arginine - Leucine - ω-3 FattyAcids -………

  16. Immunonutrients • Micronutrients -Vitamins -Selenium -Zinc -Magnesium -…….

  17. Nucleotides • Prebiotics, Probiotics, andSynbiotics

  18. Glutamine • Glutamine has a central role in -cellularenergy -cellproliferation - renalacidbasebalance -regulation of nitrogen and carbon metabolism • Glutaminesupports regulation of glucose metabolism throughimproved insulin sensitivity

  19. 2013

  20. 2004

  21. 2012

  22. 2013

  23. M1 CD80 CD86 MHCII IL-12, IL-23 TNF, IL-1, IL-6 CXCL8 CXCL9 CXCL10 CXCL11 CXCL16 CCL2 CCL3 CCL5 TLR2 TLR4 NADPH oksidaz MP iNOS CCR7 RNİ ROİ İL1R1 IL-10, TGF-b IL1Ra CCR2 CXCR1 CXCR2 DecoyIL1R2 arginaz arginaz arginaz MHCII CD14 CD150 MR, SR IL-10, IL-1Ra CD23 CD163 MR, SR CCL16 CCL18 CXCL13 CD80 CD86 MHCII CCL17 CCL18 CCL22 CCL24 IL-10, IL-1, IL-6 TNF M2c M2b M2a CCL1

  24. NKT 1 DC1 Th1 Mq2 DC2 Treg NKT 2

  25. Postbiotics

  26. PyodermaGangrenosum

  27. 2nd day 9th day 13th day 17th day

  28. ImpactFactor 3.882

  29. I’mexpecting a piece of immunenutrientsfromyou!

  30. ‘’Always find your way to the whole and if you are not a whole join it as a member’’ Goethe THANK YOU FOR YOUR ATTENTION

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