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GISSI-HF: n-3 PUFA Study

GISSI-HF: n-3 PUFA Study. No difference between the two arms for primary endpoint (death), but significant difference noted on multivariate analysis ( HR 0.91, 95.5% CI 0.83-1.0; p = 0.041)

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GISSI-HF: n-3 PUFA Study

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  1. GISSI-HF: n-3 PUFA Study No difference between the two arms for primary endpoint (death), but significant difference noted on multivariate analysis (HR 0.91, 95.5% CI 0.83-1.0; p = 0.041) No difference in the incidence of first admission for heart failure, but fewer admissions for arrhythmia related issues (p = 0.013) (p = 0.12) (p = 0.013) n-3 PUFA (n = 3,494) Placebo (n = 3,481) Trial design: Patients with symptomatic CHF were randomized to 1 g n-3 PUFA daily or placebo, in addition to optimal medical treatment. Clinical outcomes were compared at 12 months. Results 29.1 30 20 27.3 15 20 % % Conclusions 10 • No significant difference in mortality in the n-3 PUFA arm, compared with placebo in patients with symptomatic heart failure, on optimal treatment • However, multivariate analysis showed n-3 PUFA was associated with small reduction in mortality (absolute RR 1.8%) compared with placebo • Exact mechanism is unclear, although reduction in readmission for arrhythmias was noted 10 4.0 5 3.0 0 0 Arrhythmia related hospitalization Mortality GISSI-HF Investigators. Lancet 2008;Aug 31:[Epub]

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