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Alcohol Protecting Groups

Alcohol Protecting Groups. The protecting groups are used to protect primary alcohols from reacting Added before the reaction and removed after. Alcohol Protecting Groups. Silyl Ethers Tert-butyldimethylsilyl (TBDMS) Base = pyridine, imidazole Removal: fluoride ion. Triethylamine.

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Alcohol Protecting Groups

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  1. Alcohol Protecting Groups • The protecting groups are used to protect primary alcohols from reacting • Added before the reaction and removed after

  2. Alcohol Protecting Groups • Silyl Ethers • Tert-butyldimethylsilyl (TBDMS) • Base = pyridine, imidazole • Removal: fluoride ion

  3. Triethylamine Trimethylsilyl (TMS) ether TMS ether • Chlorotrimethylsilane ROH is now blocked or protected!!!

  4. Step 1: Adding Protection Group

  5. Step 2a: Carrying Out Reaction

  6. Step 2b: Carrying Out Reaction

  7. Step 3: Removing Protection Group

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