1 / 7

This is Your Title Slide With Two Lines of Text

This is Your Title Slide With Two Lines of Text. Principal Author, MD Second Author, MD PhD Third Author, MSc Institution, City, Country 23 January 2013. Text Slide. Glioblastoma Multiforme (GBM) is the most common primary brain malignant neoplasm in adults

aspen
Download Presentation

This is Your Title Slide With Two Lines of Text

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. This is Your Title SlideWith Two Lines of Text Principal Author, MD Second Author, MD PhD Third Author, MSc Institution, City, Country 23 January 2013

  2. Text Slide • Glioblastoma Multiforme (GBM) is the most common primary brain malignant neoplasm in adults • Despite constant attempts to improve outcome, the survival of patients with GBM remains limited • Currently, the standard of care consists of maximal safe surgical resection followed by External Beam Radiotherapy (EBRT) and concomitant TMZ followed by adjuvant TMZ

  3. Text Slide • Post-operative EBRT: • 60 Gy/30 daily fractions over 6 weeks • PTV margins extending to 2 to 2.5 cm from oedema/residual disease and surgical cavity • Dose response curve • Souhami, L. et al, 2004. • RTOG 9305 for SRS boost in addition to conventional EBRT • Laperrière, N. et al, 1998. • Interstitial Implant in addition to conventional EBRT

  4. Text Slide • IMRT • Concomitant boost technique • Shorten overall treatment time: reduces accelerated repopulation • Larger dose/fraction: increases cell killing • MRI co-registration • Immobilization • Treatment delivery verification • IGRT • Limited margins: reduce the normal brain volume irradiated • Reduction of treatment-related toxicity

  5. Schema • Temozolomide ¢ XRT+Temozolomide ¢ Temozolomide • Neo-adjuvant TMZ: 75 mg/m² QD will be administered for 2 weeks before starting radiotherapy • Accelerated Radiotherapy: 60 Gy in 20 fractions over 4 weeks using IMRT concomitant boost technique • Concurrent TMZ with accelerated hypofractionated radiotherapy: 75 mg/m² QD for the whole duration of radiotherapy • Adjuvant TMZ: 150 mg/m² QD for 5 consecutive days of a 28 day-cycle

  6. This is a Figure Slide

  7. Thank You

More Related