Accelerating Pharma IP Discovery using Advanced Search Technology

1. Accelerating Pharma IP Discovery using Advanced Search Technology Craig Stephens CAS Vice President, Sales

2. Agenda Introduction to Chemical Abstracts Service (CAS) Trends in chemical research publications Prodrugs - a Case Study Thursday, November 27, 2014

3. CAS is the leading global source of chemical information for scientific and patent research • Founded in 1907 to monitor, abstract, and index the world's chemistry-related literature and make it available to the scientific community • Headquartered in Columbus, Ohio

4. CAS databases provide complete access to the world of chemistry and related science

5. CAS analyzes global chemical information, including extensive coverage of patents from Asia Coming Soon Malaysia! Japanese Patent Office (JPO) Republic of Korea (KR) China (CN) Taiwan (TW) India (IN) Hong Kong (HK) Philippines (PH) Singapore (SG)

6. CAS products streamline access to CAS databases to speed the pace of scientific discovery

7. Patenting of new chemical research has accelerated, especially patenting of Chinese chemical research

8. Increasingly, new chemical discoveries are being disclosed through patent activities Percentage of New Compounds Added to CAS REGISTRY from Patents 46% Percentage of total 14% Year

9. “Patinformatics” is an emerging science that derives the “big picture” from a multitude of patent documents Searcher Analyst Broad SearchStrategy Query Large Answer Set Visualize Discovery Ideas Opportunities Strategy How has nanotechnology been used in the area of drug delivery? Which pharmaceutical companies are developing prodrugs and what technologies are they using? Thursday, November 27, 2014

10. Patinformatics: A quick study on Prodrugs Use search tools to create a document set: STN Export the document set to an analysis tool Perform analysis and visualization within STN AnaVist Automatically creates visualizations that are dynamically linked Enables evaluation based on comparisons of structured and unstructured data Apply the results to a business situation Thursday, November 27, 2014

11. Search technology can reveal new trends in drug discovery • Search tools ensure comprehensive retrieval of appropriate records • Controlled Term thesauri focus on targeted terminology used in a database • Substance search tools include structure and sequence search capabilities • Results from a technical database search can demonstrate trends • Display fields sort information for further investigation • Database tools facilitate in-depth analysis and visualization November 27, 2014

12. A thesaurus provides insight into pharmaceutical terminology and a hierarchy to broaden/narrow studies • =>FILE CAPLUS • => E PRODRUGS+ALL/CT • E1 0 BT2 Bioactive compounds (non-CA heading)/CT • E2 4081 BT2 Health products/CT • E3 43159 BT1 Drugs/CT • E4 4081 BT3 Health products/CT • E5 200542 BT2 Drug delivery systems/CT • E6 0 BT1 Pharmaceutical dosage forms (non-CA heading)/CT • E7 5509 --> Prodrugs/CT • HNTE Valid heading during volume 146 (2007) to • present. • NOTE A compound that must undergo chemical conversion • to a pharmacologically active form after • administration. • E8 OLD Drug delivery systems (L) prodrugs/CT • E9 OLD Pharmaceutical dosage forms (L) prodrugs/CT • E10 OLD Pharmaceuticals (L) prodrugs/CT • E11 UF DDS prodrugs/CT • E12 UF Drug precursors/CT • E13 UF Pharmaceutical prodrug/CT • E14 UF Pharmaceutical prodrugs/CT • E15 UF Prodrugs pharmaceuticals/CT • ********** END **********

13. Modern technology helps develop interactive visualization tools to speed drug discovery

14. The Research Landscape reveals the “big picture” in technology development

15. Competitive trends in pharmaceutical research can be discovered and explored in more depth

16. Summary • Scientific databases (CAplus) provide easy access to the rapidly increasing amount of prior art in the pharmaceutical area • Search products (STN) provide a powerful tool to precisely obtain relevant patent information • Analysis and visualization software (STN AnaVist) facilitate business decisions by: • Accurately interpreting technological trends • Identifying leading companies in drug development • Locating relevant prior art

17. Right information for right business & project decisions Improve decision-making Reduce risk STN can help leverage your IP portfolio! Increase workflow efficiency Discover new opportunities • “STN offers all important scientific databases we need. This allows comprehensive state-of-the-art searches on all our research topics.” • Dr. Bernhard Hostettler, Head of Intellectual Property Management, Prionics, Swiss Animal Health Diagnostic Company

18. The world’s major pharmaceutical companies trust information from STN

19. New five-year “single source” contract with USPTO “ • STN databases offer the largest collection and depth of chemical and related information compared to other commercial web based databases. • … CAS is the only company that has a unique, proprietary, chemical structure searching capability using its STN Express software. No other source can successfully meet the USPTO's requirements. “ USPTO, 20 August 2010

20. Thank You.