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Pharmacology-1 PHL 313

Desensitization (Tachyphylaxis) and Tolerance. The loss of a drug's effect, when it is given continuously or repeatedlyOn a short time-scale, such as a few minutes, this situation is called desensitization or tachyphylaxis and on a longer time-scale, such as days or weeks, the term tolerance is pre

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Pharmacology-1 PHL 313

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    1. Pharmacology-1 PHL 313

    4. Types of Targets for Drug Action

    5. Drug Mechanisms (How Drugs Act?) Receptor mechanisms: Most drugs exert their effects by binding to receptors This has the effect of either mimicking the bodys own (endogenous) substances binding to receptors or preventing their binding or actions

    6. Receptors Serve as recognition sites for specific endogenous compounds such as: 1. Neurotransmitters, e.g. noradrenaline (NA) 2. Hormones, e.g. adrenaline (released from the adrenal medulla and acts on the heart) 3. Local Hormones /Autacoids (released and act upon the same/nearby tissue, e.g. prostaglandins)

    7. Receptor Family Summary and Examples

    8. Action Potential

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