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Generating Spiral Waves with Different G CaL and G K1

Generating Spiral Waves with Different G CaL and G K1. Clara N. Jasmine M. Rachel S. Mark D. CMACS Workshop 2013. What do you see?. I CaL is a depolarizing inward current Affects plateau of action potential, a balancing act between depolarizing currents

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Generating Spiral Waves with Different G CaL and G K1

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  1. Generating Spiral Waves with Different GCaLand GK1 Clara N. Jasmine M. Rachel S. Mark D. CMACS Workshop 2013

  2. What do you see?

  3. ICaL is a depolarizing inward current • Affects plateau of action potential, a balancing act between depolarizing currents • Hypothesis: An increase in GCaL, increases ICaL, which will elongate the plateau Effects on Action Potential Saeneno JB, Vrints CJ. Molecular aspects of the congenital and acquired Long QT Syndrome: clinical implications. J Mol Cell Cardiol.Epub2008 Feb 9. http://www.ncbi.nlm.nih.gov/pubmed/18336833

  4. IK1, inward rectifying current, closes at depolarization • Active during resting potential and the end of Phase 3 repolarization • Hypothesis: An increase in GK1, increases IK1, which will make the repolarization slope steeper Effects on Action Potential Saeneno JB, Vrints CJ. Molecular aspects of the congenital and acquired Long QT Syndrome: clinical implications. J Mol Cell Cardiol.Epub2008 Feb 9. http://www.ncbi.nlm.nih.gov/pubmed/18336833

  5. Is there more orange in the upper right quadrant? • Is there more green as Gk1 increases? • How can we improve the testability of our hypotheses? Effects on Spiral Waves

  6. Is there more orange in the upper right quadrant? • Is there more green as Gk1 increases? • How can we improve the testability of our hypotheses? Effects on Spiral Waves

  7. Inward Rectifier K+ conductance • Higher GK1 Leads to Dispersion Increased GK1

  8. Inward Rectifier K+ conductance • Higher GK1 Leads to Dispersion Increased GK1 Gcal 25,Gk1 25

  9. Inward Rectifier K+ conductance • Higher GK1 Leads to Dispersion Increased GK1 Gcal 25,Gk1 25 Gcal 25,Gk1 145

  10. Higher value of GCaL Increased GK1

  11. Higher value of GCaL Increased GK1 Gcal 145,Gk1 25

  12. Higher value of GCaL Increased GK1 Gcal 145,Gk1 25 Gcal 145,Gk1 145

  13. L-Type Ca+2 conductance • GCaL changes pathway shape Increased GCaL

  14. L-Type Ca+2 conductance • GCaL changes pathway shape Increased GCaL Gcal 25,Gk1 45

  15. L-Type Ca+2 conductance • GCaL changes pathway shape Increased GCaL Gcal 25,Gk1 45 Gcal 125,Gk1 45

  16. Higher value of GK1 Increased GCaL

  17. Higher value of GK1 Increased GCaL Gcal 25,Gk1 185

  18. Higher value of GK1 Increased GCaL Gcal 25,Gk1 185 Gcal 185,Gk1 185

  19. Increased GK1 Leads to a Tip Trajectory Spread Out Over a Larger Area. • Increased GCal Plays a Role in the Shape of the Pathway Traced By the Tip. Conclusion

  20. CMACS Workshop • Professor Griffeth • Professor Fenton • NSF/NIH/NASA/ABC/CIA/CUNY/LOL • Peter’s Python • TNNP • Mother Nature For Developing A Complicated Heart Structure That Has Not Been Fully Understood Thus Far. Acknowledgements!!!!!!1!!

  21. Questions?

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