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Sodium Channel Structure. Sodium Channel Structure.
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Sodium Channel Structure The a subunit consists of four domains of six transmembrane segments, with the 5th and 6th segments comprising the pore formation unit. The b subunits consist of a single membrane spanning segment with an immunoglobulin-like fold in an extracellular domain. The a subunit contains the binding sites for a variety of toxins and drugs, as indicated.