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Activation and Inactivation of the Sodium Channel

Activation and Inactivation of the Sodium Channel. SIGMA-ALDRICH. Activation And Inactivation Of The Sodium Channel

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Activation and Inactivation of the Sodium Channel

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  1. Activation and Inactivation of the Sodium Channel SIGMA-ALDRICH

  2. Activation And Inactivation Of The Sodium Channel Sodium channels are characterized by voltage-dependent activation, rapid inactivation, and selective ion conductance. Depolarization of the cell membrane opens the ion pore allowing sodium to passively enter the cell down its concentration gradient . The increase in sodium conductance further depolarizes the membrane to near the sodium equilibrium potential. Inactivation of the sodium channel occurs within milliseconds, initiating a brief refractory period during which the membrane is not excitable. The mechanism of inactivation has been modeled as a “hinged lid” or “ball and chain”, where the intracellular loop connecting domains III and IV of the a subunit closes the pore and prevents passage of sodium ions. References: Lehmann-Horn, F., and Jurkat-Rott, K., Voltage-gated ion channels and hereditary disease. Physiol. Rev., 79, 1317-1372 (1999). Catterall, W.A., From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels. Neuron, 26, 13-25 (2000).

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