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INSTITUTE FOR IMMUNOBIOLOGY

INSTITUTE FOR IMMUNOBIOLOGY. 抗体研究给我们的启示 Apocalypse from the Study on Antibody Institute for Immunobiology Department of Immunology Center for Gene Immunization and Vaccine Research Fudan University 熊思东： 021-54237749 or 55664923 immfd@126.com or sdxiong@shmu.edu.cn. Shanghai, China.

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INSTITUTE FOR IMMUNOBIOLOGY

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  1. INSTITUTE FOR IMMUNOBIOLOGY 抗体研究给我们的启示 Apocalypse from the Study on Antibody Institute for Immunobiology Department of Immunology Center for Gene Immunization and Vaccine Research Fudan University 熊思东：021-54237749 or 55664923 immfd@126.com or sdxiong@shmu.edu.cn Shanghai, China

  2. 《圣经》启示录中代表瘟疫的第四骑士 杜勒，画于1498年。画中我们可以看到启示录中的四骑士，他们分别代表了预示世界末日的四种力量，战争、饥荒、死亡以及最为可怕的一个——瘟疫。

  3. Pandora and her box

  4. 唐开元间（618～）江南赵氏： 鼻苗种痘法（清《牛痘新书》》董玉山(1884) ）：“考上世无种痘，诸经自唐开元间，江南赵氏，始传势苗种痘之法”。

  5. Edward Jenner, Sarah Nelmes, Joseph Meister and his mother "Getting the jab." Jenner inoculated an 8 year old boy James Phipps with cowpox on May 14 1796. The boy died of TB at 21.

  6. 我们，全球扑灭天花证实委员会委员，证实扑灭天花已经在全世界实现。我们，全球扑灭天花证实委员会委员，证实扑灭天花已经在全世界实现。

  7. Louis Pasteur (1822-1895) 1880 Vaccine 1881 Vaccine to Anthrax 1885 Vaccine to Rabies

  8. 1905 "for his investigations and discoveries in relation to tuberculosis" Robert Koch (1843-1910) M. Tuberculosis Koch Phenomenon

  9. How does vaccine work ???

  10. Paul Ehrlich (1854-1915) Elie Metchnikoff (1845-1916) 1908 "in recognition of their work on immunity"

  11. 1888 Roux/Yersin Diphtheria toxin 1890 Behring/Kitasato Serum therapy

  12. The Nobel Prize in Physiology or Medicine 1901 "for his work on serum therapy, especially its application against diphtheria, by which he has opened a new road in the domain of medical science and thereby placed in the hands of the physician a victorious weapon against illness and deaths" Emil Adolf von Behring Marburg University Marburg, Germany 1854 - 1917

  13. 1897 Ehrlich Humoral immunity

  14. 1917 Liverpool U. 1946 Cambridge U. 1972 Nobel Prize 1985 Rodney R. Porter

  15. 110KD: 分子量太大

  16. Antibody:Fab Fc Single chain

  17. 1929 生于纽约 1950 学士 1954 宾大博士 1957 洛克菲勒大学 Gerald M. Edelman

  18. Antibody:H L

  19. H Ab L Ab Anti-H Anti-L Fab + + Fc + -

  20. 抗体的 基本结构 1）四肽链通过链间二硫键组成H2L2 重链：450aa, Mr.5X104,五类(a、g、m、d、e) 轻链：214aa, Mr.2.5X104 ,两型(k、l) 2）分三个功能区： 可变区(Variable region, VH/VL, Fv)：结合抗原 恒定区(Constant region, CH/CL)：次级反应、抗原性 绞链区(Hinge region)CH1-CH2间, 30aa,2-5链间二硫键 3）蛋白酶可酶解 木瓜蛋白酶(papain)：Fab、 Fc 胃蛋白酶(pepsin)： F(ab’)2 →2XFab’、pFc’

  21. The Nobel Prize in Physiology or Medicine 1972 Rodney R. Porter Gerald M. Edelman for their discoveries concerning the chemical structure of antibodies

  22. Argentina and United Kingdom MRC Laboratory of Molecular Biology Cambridge, United Kingdom b. 1927(in Bahia Blanca, Argentina)d. 2002 César Milstein

  23. Federal Republic of Germany Basel Institute for Immunology Basel, Switzerland b. 1946d. 1995 Georges J.F. Köhler

  24. the Nobel Prize in Physiology or Medicine for 1984 César Milstein Georges J.F. Köhler for the discovery of the principle for production of monoclonal antibodies

  25. P. Ehrlich Side-chain theory

  26. Clonal selection Sir FM Burnet (1899-1985)

  27. The Self-Nonself Model Burnet’s original model each lymphocyte expresss mutiple copies of a single surface receptor specific for a foreign entity. signaling through this surface antibody initiates the immune response. the self-reactive lymphocytes are deleted early in life

  28. The Nobel Prize in Physiology or Medicine 1987 Susumu Tonegawa (1939-) , MIT "for his discovery of the genetic principle for generation of antibody diversity"

  29. The Nobel Prize in Physiology or Medicine 1984 Niels K. Jerne for theories concerning the specificity in development

  30. 1 杀伤性T细胞对 靶细胞的杀伤作用 2 3

  31. Classic experiment of Zinkernagel and Doherty demonstrating that Ag recognition by T cells exhibits MHC restriction

  32. Clonal selection

  33. Dual receptor model Altered-self model

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