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University of Windsor Animal User Training Program. Gwendolyn Jeun, D.V.M. Honours Bachelor of Science, Zoology (UWO) Master of Science, Zoology (UWO) Doctor of Veterinary Medicine (Ontario Veterinary College, U of Guelph) Aquavet, Woods Hole Mystic Marinelife Aquarium, Connecticut.
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Gwendolyn Jeun, D.V.M. • Honours Bachelor of Science, Zoology (UWO) • Master of Science, Zoology (UWO) • Doctor of Veterinary Medicine (Ontario Veterinary College, U of Guelph) • Aquavet, Woods Hole • Mystic Marinelife Aquarium, Connecticut
Legislation and Regulation • Canadian Council on Animal Care • OMAFRA - “Animals for Research Act” • University of Windsor Animal Care Committee • Ministry of Natural Resources etc. for fieldwork and wildlife
Canadian Council on Animal Care (CCAC) www.ccac.ca
Canadian Council on Animal Care (CCAC) The Three Rs • Reduction • Refinement • Replacement
The Three R’s www.altweb.jhsph.edu Center for Alternatives to Animal Testing at Johns Hopkins University -to foster development of scientifically acceptable in vitro & other R-R-R alternatives for animal testing
Replacement • are there appropriate alternatives?
Refinement • achieve expertise • limit pain • prevent wasting of animals • expertise can reduce variability thus reducing numbers required
Reduction • appropriate animal numbers - statistical requirements • controlling variability • literature researches
CCAC How does CCAC accomplish its goals? 3 Rs Guidelines Assessment Education
CCAC Guidelines • “Guide to the Care and Use of Experimental Animals, Volumes 1 & 2” • Vol 1 - principles for good animal care and use • Vol 2 - husbandry of experimental animals on a species by species basis • Available through www.ccac.ca
Assessment • CCAC assessment panel carries out site visits to ensure guidelines are being followed • status of compliance, conditional compliance or non-compliance • if non-compliant, CCAC can inform granting agencies (e.g. NSERC)
Education • via CCAC assessment panel • CCAC workshops for members of Animal Care Committee • National Institutional Animal User Training Program (NIAUT) - ensures all personnel are trained in basic principles of lab animal science and ethical issues
Ontario Ministry of AgricultureFood and Rural Affairs(OMAFRA) www.gov.on.ca/OMAFRA
Animals for Research Act • provincial legislation protecting all animals used in research and testing • applies to all vertebrates - fish, rodents, reptiles, birds, primates and livestock • OMAFRA responsible for administering and enforcing the law
Required by law • Animal Care Committee at U of W • Research Proposals or Protocols
Objectives of the Act • maintain a minimum standard of care • protect research animals from unnecessary pain • assure that dogs and cats used for research are obtained legally
Key elements of the Act • minimum standards of housing and care • animal care committees • research proposals • veterinary inspectors • dog pounds and supply facilities • pet protection
Housing and Care • cage size, construction, cleanliness • food, water and bedding • ventilation, temperature, humidity • transportation of animals • surgical facilities and procedures must meet established veterinary standards
Protocols • must be submitted well before animal use is to begin so ACC can review: -suitable animal numbers - appropriate species - appropriate procedures - unnecessary pain/discomfort - scientific work
Veterinary Inspectors • unannounced visits • authority to enter any area where they believe animal research is taking place • inspect all aspects of animal use to ensure it meets the requirements of the Act • can revoke registration of research facility and lay court charges
U of W Animal Care Committee (ACC) • required by both CCAC and “Animals for Research Act” • ensures that all animal use meets guidelines • accomplished via: • research and teaching protocols • training and information sessions • veterinary inspections
ACC Members • Vice President Research • representative from each user department • non-animal user from University • community lay person • veterinarian • student representative • others as needed
Animal Facilities • Great Lakes Institute • Biology • Psychology • Human Kinetics (not active currently)
Wildlife and Fieldwork • all the same rules and regulations apply, PLUS • additional laws and permits • Migratory Birds Convention Act • Game Export Act • provincial Fish and Wildlife Acts • Convention on International Trade in Endangered Species (CITES)