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Inhaled Drugs

UABD – Nebulized Liquid. Inhaled Drugs. MDI – Pressurized Meter Dose Inhaler Canister. DPI – Dry Powder Inhaler. Classifications by Mechanism . I. Bronchodilators – Reduces bronchial smooth muscle constriction II. Corticosteroids – Reduce bronchial wall inflammation (swelling)

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Inhaled Drugs

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  1. UABD – Nebulized Liquid Inhaled Drugs MDI – Pressurized Meter Dose Inhaler Canister DPI – Dry Powder Inhaler

  2. Classifications by Mechanism I. Bronchodilators – Reduces bronchial smooth muscle constriction II. Corticosteroids – Reduce bronchial wall inflammation (swelling) III. MucoactiveAgents – has an effect on mucus IV. Antimicrobial – kills microorganisms V. Other

  3. I. Bronchodilators A. Short Acting - 1) Beta Agonists: Albuterol 2.5 mg Xopenex 1.25 mg 2) Anti Cholinergic: Atrovent (Ipratropium Bromide) B. Long Acting - Serevent (in Advair) Spiriva Rescue Drug

  4. Short Acting Beta Agonists (beta-2)

  5. II. Steroids • Flovent (in Advair) • Pulmicort (MDI or UABD) • Aerobid • Qvar Controller Must use as directed may take several doses/days to have therapeutic effect!

  6. Most come in MDI / DPI

  7. III. Mucoactive Agents • Normal saline – is the carrier in UABD treatments (MDI version doesn’t have) • Acetylcystine – Mucomyst 10%-20% solutions – irritating and smells! (give with a bronchodilator • NaHCO3- (Bicarbonate solution) • Pulmozyme – expensive $$$

  8. IV. Antimicrobials • Pentamidine – Pneumocystis • Tobi (Tobramycin) G- bacteria • Colystin – bacteria • Ribrivirin

  9. V. Others • Chromolyn Sodium – allergy drug • Lidocaine – numbing medicine

  10. Da rules: • Don’t give drugs in the exact same class together: • examples: • Pulmicort & Flovent (both steroids) • Xopenex and Albuterol (both short acting beta agonists)

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