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DNA Repair as a Therapeutic Target

DNA Repair as a Therapeutic Target. DNA Repair SIG breakfast meeting Puerto Rico, October 19, 2008. Gleevec Iressa flavopyridol. DNA-PK. NHEJ. vanillin, OK-1035 NU7441 NU7026 IC87361 LY294002. DNA Ligase IV. ABT-888 KU0059436 KU0058684 BSI-201 GPI21016 AG014699 AG14361

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DNA Repair as a Therapeutic Target

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  1. DNA Repair as a Therapeutic Target DNA Repair SIG breakfast meeting Puerto Rico, October 19, 2008

  2. Gleevec Iressa flavopyridol DNA-PK NHEJ vanillin, OK-1035 NU7441 NU7026 IC87361 LY294002 DNA Ligase IV ABT-888 KU0059436 KU0058684 BSI-201 GPI21016 AG014699 AG14361 INO-1001 3-AB ISQ NU1025 L189 PARP HR Rad51 Target #1: DNA Repair

  3. UCN-01 XL844 PF-00477736 AZD7762 Go6976 SB-218078 CEP-3891 UCN-01 XL844 PF-00477736 AZD7762 CEP-6367 KU 55933 nutlins Prima-1 RITA MI-219 pifitherin CBLB502 Chk1 Chk2 ATM p53 Target #2: DNA Damage Signaling

  4. survivin gambolic acid FTS NU6140 selenium asprin celecoxib hedamycin flavopyridol Bcl-2 Bcl-XL 2-MeAA gossypol ApoG2 ABT-737 ABT-263 TW-37 Zfra GX15-070 HA14-1 YC137 Apoptosis EGFR AKT RAS Mcl-1 cetuximab (C225) trastuzumab ZD1839 CI-1033 A-443654, SH-5, LY294002, OSU-03012, perifosine, celecoxib ApoG2, TW-37, BAY 43-9006, roscovitine, flavopyridol farnesyl transferase inhibitors: FTI-277 L744832 BIM-46228 Target #3: Cell survival

  5. senescence “replication stress” DNA damage response premature entry into S-phase apoptosis Oncogenes induce DNA damage! activated oncogene X

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