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Coronary Phantom Design for K-edge Angiography

Coronary Phantom Design for K-edge Angiography. John Jorgensen Sarah Pachtman Punam Patel Marcus Spallek Advisor: Dr. Frank Carroll. MXI Systems. MX 200 Applications Radiotherapy Crystallography Mammography Pediatrics K-edge Imaging Angiography???.

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Coronary Phantom Design for K-edge Angiography

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  1. Coronary Phantom Design for K-edge Angiography John Jorgensen Sarah Pachtman Punam Patel Marcus Spallek Advisor: Dr. Frank Carroll

  2. MXI Systems • MX 200 • Applications • Radiotherapy • Crystallography • Mammography • Pediatrics • K-edge Imaging • Angiography??? http://www.onlinetelemedicine.com/html/product/sam_images/Angiography.jpg

  3. Project Background • Monochromatic tunable X-ray: • Reduced radiation dose to patient • Reduced contrast agent concentrations • K-edge imaging Diagram of MX200’s laser paths and major elements. http://www.mxisystems.com/mx200.html FOR MORE INFO... Free Electron Laser Laboratory  http://www.vanderbilt.edu/fel/

  4. K-edge Effect

  5. Project Goals • Design acoronary phantom • Test contrast agent concentrations • hypersensitivity reaction to iodine (3-12% patients) • current clinical dilution is 1:16 • using monochromatic plain films it is possible to see 1:256 dilutions • Determine optimal angle for stereo imaging Tan θ = 3/30 = 0.10 θ ~ 6° 3” θ 30”

  6. Solution Description • Radio Translucent at 35 keV • Flexible material • Fluid perfusion • Phantom Size • 7.5cm diameter • Vasculature • Size Range 5 - 1 mm • Coronary arteries on surface • Curved channels • Hollow vessels Finger imaged at 19 keV Finger imaged at 26 keV

  7. Phantom Designs Shelley Medical Imaging Technologieswww.simutech.com SolidWorks Model Preliminary Sketch

  8. Ideal Material ReoFlex™ 20 polyurethane resin Actual Material Z-Corp’s ZP 102 plaster-based powder Compatible with printing machine used for prototyping process Ideal for printing fine-detail or thin-walled models Radiotranslucent and flexible formulation Option to infiltrate with Synair Corporation Por-A-Mold polyurethane resin Material Considerations

  9. November December January February March April Schedule Research Material Testing & Design Manufacturing Testing FOR MORE INFO... http://vubme.vuse.vanderbilt.edu/srdesign/2003/group12/NCIIA%20Grant%20Proposal.htm

  10. Current Status • Work Completed • Design Finalized • Manufacturer Contacted • Prototype Being Made • Expected by Early Next Week

  11. Future Plans • April • Create Pump for Dosimetry Testing • Start Testing • Test Dosimetry for Imaging • Test for Optimal Stereo Angle • Write Final Report • Create Poster

  12. Testing • Create Pump for Dosimetry Testing • Run Tests • Test Dosimetry for Imaging • Acquire series of images with different dilutions of contrast agent • Test for Optimal Stereo Angle • Acquire series of images at different rotation angles

  13. Team and Resources • Advisor: Dr. Frank Carroll, M.D. • Monochromatic x-ray machine • W.M. Keck Free-electron Laser (FEL) Center at Vanderbilt University • Materials and tools provided by BME Department and FEL Center • Polyurethane resins from outside contractors Photograph of device with laser cover removed http://www.vanderbilt.edu/fel/Xray/manuscripts/final%20report%20for%20ONR%20grant%2020021218.doc

  14. Questions? Home

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