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Chapter 4. Histology: The Study of Tissues. Tissues and Histology. Tissues are collections of similar cells and the substances that surround them. Tissue Level of Organization Epithelial Connective Muscle Nervous Histology : Microscopic Study of Tissues. Epithelium Characteristics.
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Chapter 4 Histology: The Study of Tissues
Tissues and Histology • Tissues are collections of similar cells and the substances that surround them. • Tissue Level of Organization • Epithelial • Connective • Muscle • Nervous • Histology: Microscopic Study of Tissues
Epithelium Characteristics • Consists almost entirely of cells • Covers body surfaces and forms glands • Has free and basal surface • Specialized cell contacts • Avascular • Undergoes mitosis
Functions of Epithelia • Protecting underlying structures • Acting as barriers • Permitting the passage of substances • Secreting substances • Absorbing substances
Classification of Epithelium • Simple • Squamous, cuboidal, columnar • Stratified • Squamous, cuboidal, columnar • Pseudostratified • columnar • Transitional • Cuboidal to columnar when not stretched and squamouslike when stretched
Functional Characteristics • Cell layers and shapes • Diffusion, Filtration, Secretion, Absorption, Protection • Cell surfaces • Microvilli: Increase surface area absorption or secretion • Cilia: Move materials across cell surface • Cell connections • Desmosomes, tight, gap • Glands • Exocrine: Have ducts • Endocrine: Have no ducts
Cell Connections • Functions • Bind cells together • Form permeability layer • Intercellular communication • Types • Desmosomes • Tight • Gap
Exocrine Glands • Unicellular • Goblet cells
Exocrine Glands and Secretion Types • Merocrine • Sweat glands • Apocrine • Mammary glands • Holocrine • Sebaceous glands
Connective Tissue • Abundant • Consists of cell separated by extracellular matrix • Diverse • Performs variety of important functions
Functions of Connective Tissue • Enclosing and separating as capsules around organs • Connecting tissues to one another as tendons and ligaments • Supporting and moving as bones • Storing as fat • Cushioning and insulating as fat • Transporting as blood • Protecting as cells of the immune system
Connective Tissue Cells • Specialized cells produce the extracellular matrix • Suffixes • -blasts: create the matrix • -cytes: maintain the matrix • -clasts: break the matrix down for remodeling • Adipose or fat cells • Mast cells that contain heparin and histamine • White blood cells that respond to injury or infection • Macrophages that phagocytize or provide protection • Stem cells
Extracellular Matrix • Components • Protein fibers • Collagen which is most common protein in body • Reticular fill spaces between tissues and organs • Elastic returns to its original shape after distension or compression • Ground substance • Shapeless background • Fluid
Connective Tissue Categories • Embryonic or mesenchyme • Adult • Loose • Dense • Connective tissue with special properties • Cartilage • Bone • Blood
Loose Connective Tissue • Also known as areolar tissue • Loose packing material of most organs and tissues • Attaches skin to underlying tissues • Contains collagen, reticular, elastic fibers and variety of cells
Dense Connective Tissue • Dense regular • Has abundant collagen fibers • Tendons: Connect muscles to bones • Ligaments: Connect bones to bones • Dense regular elastic • Ligaments in vocal folds • Dense irregular • Scars • Dense irregular collagenous • Forms most of skin dermis • Dense irregular elastic • In walls of elastic arteries
Connective Tissue with Special Properties • Adipose tissue • Consists of adipocytes • Types • Yellow (white) • most abundant, white at birth and yellows with age • Brown • found only in specific areas of body as axillae, neck and near kidneys • Reticular tissue • Forms framework of lymphatic tissue • Characterized by network of fibers and cells
Cartilage • Composed of chondrocytes located in spaces called lacunae • Next to bone firmest structure in body • Types of cartilage • Hyaline • Fibrocartilage • Elastic
Hyaline Cartilage • Found in areas for strong support and some flexibility • Rib cage and cartilage in trachea and bronchi • Forms most of skeleton before replaced by bone in embryo • Involved in growth that increases bone length
Fibrocartilage • Slightly compressible and very tough • Found in areas of body where a great deal of pressure is applied to joints • Knee, jaw, between vertebrae
Elastic Cartilage • Rigid but elastic properties • External ears, epiglottis
Bone • Hard connective tissue that consists of living cells and mineralized matrix • Organic and inorganic • Types • Cancellous or spongy bone • Compact bone
Blood • Matrix between the cells is liquid • Hemopoietic tissue • Forms blood cells • Found in bone marrow • Yellow • Red
Muscle Tissue • Characteristics • Contracts or shortens with force • Moves entire body and pumps blood • Types • Skeletal • Striated and voluntary • Cardiac • Striated and involuntary • Smooth • Nonstriated and involuntary
Nervous Tissue • Found in brain, spinal cord and nerves • Ability to produce action potentials • Cells • Nerve cells or neurons • Consist of dendrites, cell body, axons • Consist of multipolar, bipolar, unipolar • Neuroglia or support cells
Membranes • Mucous • Line cavities that open to the outside of body • Secrete mucus • Serous • Line cavities not open to exterior • Pericardial, pleural, peritoneal • Synovial • Line freely movable joints • Produce fluid rich in hyaluronic acid
Inflammation • Response when tissues damaged or with an immune response • Manifestations • Redness, heat, swelling, pain, disturbance of function • Mediators • Include histamine, kinins, prostaglandins, leukotrienes • Stimulate pain receptor and increase blood vessel permeability
Tissue Repair • Substitution of viable cells fordead cells • Skin repair • Primary union: Edges of wound close together • Wound fills with blood • Clot forms • Scab • Pus • Granulation tissue • Scar • Secondary union: Edges of wound not close • Clot may not close gap • Inflammatory response greater • Wound contraction occurs leading to greater scarring
Tissues and Aging • Cells divide more slowly in older than younger people • Tendons and ligaments become less flexible and more fragile • Arterial walls become less elastic • Rate of blood cell synthesis declines in elderly • Injuries are harder to heal in elderly