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James Hassell

No fear no risk! Human risk behavior is affected by chemosensory anxiety signals Katrin Haegler ,  Rebekka Zernecke ,  Anna Maria Kleemann ,  Jessica Albrecht,  Olga Pollatos , Hartmut Brückmann ,  Martin Wiesmann. James Hassell. Hey, back o da line!. Vomeronasal Organ.

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James Hassell

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  1. No fear no risk! Human risk behavior is affected by chemosensory anxiety signals KatrinHaegler,  RebekkaZernecke,  Anna Maria Kleemann,  Jessica Albrecht,  Olga Pollatos, HartmutBrückmann,  Martin Wiesmann James Hassell Hey, back o da line!

  2. Vomeronasal Organ

  3. 1) Females prefer intact males compared to castrated males in a testosterone dependent manner 2) Male sexual pheromones are nonvolatile or contain critical nonvolatile compounds 3) Male-derived volatiles alone are not innately attractive to females

  4. VTA lesions to dopamine neurons shows a correlation to sucrose preference but not male pheromone preference Systemic injection of a dopamine antagonist did not disrupt preference for soiled bedding but an indirect agonist did. Meaning if you destroy VTA dopamine neurons your preference for sucrose goes away but your preference for male bedding does not.

  5. Possible alternative pathways for the chemosignal rewards to traverse

  6. Orbitofrontal Cortex fMRI fMRI Intensity: Androstadinone >Neutral Sweat Sexual Sweat > Neutral Sweat Pleasantness: Phenyl-Ethyl-Alcohol(PEA) > Sexual & Neutral Sweat Physiological Intensity: Androstadinone < PEA Androstadinone < Sexual Sweat < Neutral Sweat Pleasantness: Androstadinone > Sexual Sweat Androstadinone > Neutral Sweat Sexual Sweat Neutral Sweat ANDR PEA

  7. Example of what the Haegler’s Risk Game looks like

  8. Card Shown Considered Risky Considered Risky Card Chosen

  9. Winner Loser

  10. The subjects in the anxiety condition had significantly higher reported anxiety at every time point compared to the subjects in the exercise condition

  11. (0 – 100; 0 easy , 100 difficult) It was easy to play (0 – 100; 0 positive , 100 negative) Meh emotionally (0 – 100; 0 calm , 100 aroused) Not brain surgery (0 – 100; 0 not familiar , 100 very ) Have not seen this No sex differences were observed in the pilot study

  12. Normal people range is between 94 and 106 for standard values (SV) for concentration performance

  13. Very unpleasant Significantly more pleasant Very unpleasant Intense Significantly less Intense Intense Neither Neither Neither Sexually unattractive Sexually unattractive Sexually unattractive Slightly negative Slightly negative Slightly positive Rather calm Rather calm Rather calm Neither Neither Neither Slightly tired Slightly tired Slightly tired Slightly negative Slightly negative Slightly negative Slightly aroused Slightly aroused Slightly aroused Slightly alert Slightly alert Slightly alert

  14. The people who were exposed to anxiety sweat made significantly more “2 lower” “9 higher” selections than exercise sweat & controls!!!

  15. I bet it’s low!!!!!!...No wait…maybe…low!!

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