1 / 15

I nstitut des N eurosciences de M ontpellier

I nstitut des N eurosciences de M ontpellier. The large maf protein family in the development and the physiopathology of somatosensory circuitry. Pr. Martyn Goulding. Dr. P. Carroll. Pr. Jean Valmier. P. Carroll. I nstitut des N eurosciences de M ontpellier. Somesthesia.

ayita
Download Presentation

I nstitut des N eurosciences de M ontpellier

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Institut des Neurosciences de Montpellier The large maf protein family in the development and the physiopathology of somatosensory circuitry Pr. MartynGoulding Dr. P. Carroll Pr. Jean Valmier

  2. P. Carroll Institut des Neurosciences de Montpellier Somesthesia Thermoception (temperature) Mechanoception (touch) Proprioception (muscle and joints) Nociception (pain) • Somatosensory system = perception of the environment • Sensorymodalities:

  3. Arrangement of spinal nerves

  4. Specific types of mechanosensory stimulation are transduced by specific types of receptor cells.

  5. Dorsal root ganglion (DRG) Spinal cord Proprioceptors TrkC/NT-3 Mechanoreceptors TrkB/BDNF Nociceptors Thermoceptors TrkA/NGF Ret/GDNF

  6. Flexion Reflex: Withdrawal from Painful Stimuli Figure 13-8: Flexion reflex and the crossed extensor reflex

  7. P. Carroll Institut des Neurosciences de Montpellier History of the collaboration Symposium “Somatosensation and Pain” Max-Delbruck Centre, Berlin - May 2008 M. Goulding Salk Institute/UCSD San Diego USA P. Carroll J. Valmier INM/UMII Montpellier France

  8. P. Carroll known Hypothetic Institut des Neurosciences de Montpellier Discovery of marker of I° touch sensing neurons Carroll/Valmier INM/UMII, Montpellier Discovery of marker of 2° touch sensing neurons Goulding Salk/UCSD I Why collaborate? II I/II III DRG DRG IV III/IV Spinal Cord Spinal Cord Hypothesis: MafA labels neurons connected in Sensori-motor circuits

  9. P. Carroll Institut des Neurosciences de Montpellier People involved Team: Neural differentiation and connectivity in the somatosensory system Team: Molecular Neurobiology Lab P. Carroll (DR2 CNRS) J. Valmier (Pr UMII) I. Méchaly (MCU, UMII) A. Fichard (MCU, UMII) A. Garces(Chercheur INSERM) S. Venteo (IE INSERM) S. Moussa (Ph.D. Student UMII) M. Goulding M. Garcia del Barrio K. Grossmann S. Bourane

  10. P. Carroll Institut des Neurosciences de Montpellier Funding • Mobility • Shared tools • Running costs 220 k$ • 1 Ph. D. student salary for 3 years • Montpellier ~ 100 k€

  11. P. Carroll Institut des Neurosciences de Montpellier Assessment of the projectso far • Scientific collaboration - from Sept 2009 2010 Montpellier: Validation of MafA-GFP transgenic mice April 2011: send mice to Salk Institut 2011 San Diego: June 2011. S. Moussa will do neuronal tracing studies on MafA-GFP mice in San Diego 2011 San Diego: Finish creation of MafA-flipase transgenic mice July 2011: send mice to Montpellier

  12. P. Carroll Institut des Neurosciences de Montpellier Assessment of the projectso far France USA M. Goulding • Mobility Sept 2009 Meeting Post-doc training Jan 2010 S. Bourane M. Goulding S. Bourane July 2010 Meeting Nov 2010 P. Carroll A. Garces S. Venteo S. Moussa Meeting June 2011 S. Moussa Experiments on tracing neuronal connection

  13. P. Carroll Institut des Neurosciences de Montpellier Benefits of PUF program • Structuration of the collaboration • Maintain our leader position in this research area • Mobility – discussions, training, motivation …. • New collaborators – Birchmeier group in Berlin • - future network on somatosensation research?

  14. P. Carroll Institut des Neurosciences de Montpellier MERCI!

  15. P. Carroll Institut des Neurosciences de Montpellier Somatosensory system Skin • Thermonociception • Mechanoception • Proprioception Muscle spindle

More Related