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By: Austin Schulte & Brendan Logan P. 4. sickle-cell Anemia. Background/History. Discovered in 1910 The disease is said to have originated in Africa, but it was first discovered in United States.
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By: Austin Schulte & Brendan Logan P. 4 sickle-cell Anemia
Background/History • Discovered in 1910 • The disease is said to have originated in Africa, but it was first discovered in United States. • Dr. Ernest Irons examined one of his patients blood under a microscope and noticed that they were in the shape of sickle.
Causes • It is caused by Hemoglobin S which is an abnormal type of Hemoglobin. • It causes the blood cells to be misshaped. • You have to inherit the gene from both parents. • If only one of your parents has the gene you will inherit but you will not show effects of the disease.
Symptoms • Fatigue • Shortness of breath • Rapid heart rate • Abdominal pain attack • Ulcers (in lower legs) • Over time the spleen fails • Yellowing of eyes and skin
Treatment • The only way to fully cure the disease is a bone marrow transplant or a blood transfusion. • Patients are advised to take penicillin to prevent deadly diseases and folic acid which creates new blood cells. • People with the disease should drink plenty of water, get lots of rest and avoid too much physical activity.
Fun Facts • Healthy blood cells can survive for up to 120 days, but sickle-cells can only live for 10 – 20 days. • People who are heterozygous for sickle-cell anemia have an unknown immunity to malaria. • About 1 out of every 500 African babies born in the United States is born with sickle-cell anemia.
Works Cited • Genetic Science Learning Center. "Sickle Cell Disease." Learn.Genetics 19 February 2013 http://learn.genetics.utah.edu/content/disorders/whataregd/sicklecell/ • Board, A.D.A.M. Editorial. "Sickle Cell Anemia." Sickle Cell Anemia. U.S. National Library of Medicine, 18 Nov. 0000. Web. 19 Feb. 2013. <http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001554/>. • "Malaria and the Red Cell." Malaria and the Sickle Hemoglobin Gene. Harvard, 2 Apr. 2002. Web. 19 Feb. 2013. <http://sickle.bwh.harvard.edu/malaria_sickle.html>. • Staff, Mayo Clinic. "Definition." Mayo Clinic. Mayo Foundation for Medical Education and Research, 26 Mar. 2011. Web. 19 Feb. 2013. <http://www.mayoclinic.com/health/sickle-cell-anemia/DS00324/DSECTION%3Dtreatments-and-drugs>. • Winter, William P. "A Brief History of Sickle Cell Disease." A Brief History of Sickle Cell Disease. Howard, n.d. Web. 19 Feb. 2013. <http://www.sicklecell.howard.edu/ABriefHistoryofSickleCellDisease.htm>.