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Therapeutic Radionuclide Generators 1: 90Sr

Topics. 90Y as a therapeutic radionuclide90Y radiopharmaceuticals90Sr/90Y generator optionsElectrochemical 90Sr/90Y generator90Y issues in quality control of 90YExtraction paper chromatography (EPC). 90Y. AdvantagesT1/2 64 h2.28 MeV b-maxNo gammasCan be locally produced using a generatorH

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Therapeutic Radionuclide Generators 1: 90Sr

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    1. Therapeutic Radionuclide Generators 1: 90Sr/90Y Generator & Issues in Quality control of 90Y M.R.A.Pillai Division of Physical and Chemical Sciences International Atomic Energy Agency Vienna, Austria

    2. Topics 90Y as a therapeutic radionuclide 90Y radiopharmaceuticals 90Sr/90Y generator options Electrochemical 90Sr/90Y generator 90Y issues in quality control of 90Y Extraction paper chromatography (EPC)

    3. 90Y Advantages T1/2 64 h 2.28 MeV b-max No gammas Can be locally produced using a generator High specific activity, suitable for targeted therapy Very good chemistry, +3 chemistry Good ligands are available Established, efficacious radiopharmaceuticals

    4. 90Y Radiopharmaceuticals Rheumatoid arthritis: 90Y-Silicate/citrate colloid Liver cancers: 90Y-microsphere (glass or resin) Non-Hodgkin’s lymphoma: 90Y-Ibritumomab (zevalin) 90Y-DOTATATE- Neuroendocrine tumours Bone pain palliation: 90Y-EDTMP (?)

    5. 90Y radiopharmaceuticals Disease Lymphoma Breast cancer Colon cancer Pancreatic cancer Liver cancers Lung, prostate, breast cancers Targeting molecule 90Y-Epratuzomab 90Y-Anti-CEA mAb 90Y-pretargeted bispecific Ab 90Y-PAM4 Ab 90Y-Anti-CEA mAb 90Y-Bombesin/GRP analog

    6. Issues related to 90Y-based radiopharmaceuticals Availability of 90Y, T1/2 64 h High cost (10-15 Euro/mCi) Import is ruled out for most countries Local production mandatory

    7. Production of 90Y Reactor production 89Y(n,g)90Y Yttrium is mononuclidic Pure target Very small cross section 0.001 barns High flux reactor needed Very low specific activity Not suitable for targeted therapy

    8. Solution Local production Option: 90Sr/90Y generator

    9. Why do we need to have a generator? Price of 90Y is ~ 10-15 Euros per mCi Landed cost of 90Y will depend on how far is the user from the supplier 64 hour half life is too short to take care of transportation logistics Limited or no suppliers

    10. Concerns Long term characteristics of the generator A QC procedure that can be adapted in a hospital radiopharmacy to assure below permissible limits of 90Sr in 90Y MPBB of 90Sr is 74 kBq Assuming that a patient will receive 1 Ci of 90Y, the 90Sr in one Ci should not be more than 2 mCi or 2 ppm

    11. 90Sr/90Y Generator 90Sr: T1/2 28.68 Y Ebmax 0.546 MeV 90Y: T1/2 64 h Ebmax: 2.28 MeV 90Zr is stable Decay scheme of 90Sr

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