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CHMI 2227E Biochemistry I

CHMI 2227E Biochemistry I. Introduction. What is Biochemistry?. What is Biochemistry?. What do biochemists do?. Normal mouse. Mighty mouse. Example 1 Myostatin deficiency and muscular development. Example 2 Leptin deficiency and obesity. 7 FEBRUARY 2003 VOL 299 SCIENCE.

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CHMI 2227E Biochemistry I

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  1. CHMI 2227EBiochemistry I Introduction CHMI 2227 - E.R. Gauthier, Ph.D.

  2. What is Biochemistry? CHMI 2227 - E.R. Gauthier, Ph.D.

  3. What is Biochemistry? CHMI 2227 - E.R. Gauthier, Ph.D.

  4. What do biochemists do? CHMI 2227 - E.R. Gauthier, Ph.D.

  5. Normal mouse Mighty mouse Example 1Myostatin deficiency and muscular development CHMI 2227 - E.R. Gauthier, Ph.D.

  6. Example 2Leptin deficiency and obesity 7 FEBRUARY 2003 VOL 299 SCIENCE • Boy with an inherited deficiency in the gene encoding leptin • Top: at age 3 • Bottom: same boy, at age 8, after years of treatment with leptin CHMI 2227 - E.R. Gauthier, Ph.D.

  7. Example 3:Hutchinson-Gilford Progeria Syndrome http://seattlepi.nwsource.com/specials/seth/190915_progeriaweek.asp CHMI 2227 - E.R. Gauthier, Ph.D.

  8. Ultrastructure of life - the AIDS virus Lipids Nucleic acids Proteins Sugars CHMI 2227 - E.R. Gauthier, Ph.D. http://en.wikipedia.org/wiki/Image:800px-HIV_Viron.png

  9. Lipids Nucleic acids Proteins Sugars Ultrastructure of life - A bacteria http://en.wikipedia.org/wiki/Image:Prokaryote_cell_diagram.svg CHMI 2227 - E.R. Gauthier, Ph.D.

  10. 1- Nucleolus Synthesis of ribosomes 2- Nucleus Contains DNA Site of DNA and RNA synthesis 3- Ribosome Contains RNA and proteins Site of protein sythesis 4 –secretory vesicle Transport 5- rough endoplasmic reticulum Cellular highway 6- Golgi appatarus Cellular highway Sugarland! Ultrastructure of life - A mammalian cell http://en.wikipedia.org/wiki/Image:Biological_cell.svg CHMI 2227 - E.R. Gauthier, Ph.D.

  11. 7- Cytoskeleton Scaffold 8- Smooth endoplasmic reticulum Cellular highway 9- Mitochondria Powerhouse 10 –Vacuole Storage 11- Cytoplasm Cellular Jello 12 – Lysosome Digestive organ of the cell 13 – Centriole Makes flagella/cilia Required during cell division Ultrastructure of life - A mammalian cell http://en.wikipedia.org/wiki/Image:Biological_cell.svg CHMI 2227 - E.R. Gauthier, Ph.D.

  12. Red: mitochondria Blue: Nucleus Green: cytoskeleton http://probes.invitrogen.com/servlets/photo?fileid=g001835&company=probes CHMI 2227 - E.R. Gauthier, Ph.D.

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