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Exploring Biochemistry: From Cells to Organisms

Discover the fascinating world of biochemistry - from cellular structures to complex organisms. Understand the role of lipids, nucleic acids, proteins, and sugars in life processes. Learn about genetic disorders and cellular components such as the nucleus, mitochondria, and more.

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Exploring Biochemistry: From Cells to Organisms

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  1. CHMI 2227EBiochemistry I Introduction CHMI 2227 - E.R. Gauthier, Ph.D.

  2. What is Biochemistry? CHMI 2227 - E.R. Gauthier, Ph.D.

  3. What is Biochemistry? CHMI 2227 - E.R. Gauthier, Ph.D.

  4. What do biochemists do? CHMI 2227 - E.R. Gauthier, Ph.D.

  5. Normal mouse Mighty mouse Example 1Myostatin deficiency and muscular development CHMI 2227 - E.R. Gauthier, Ph.D.

  6. Example 2Leptin deficiency and obesity 7 FEBRUARY 2003 VOL 299 SCIENCE • Boy with an inherited deficiency in the gene encoding leptin • Top: at age 3 • Bottom: same boy, at age 8, after years of treatment with leptin CHMI 2227 - E.R. Gauthier, Ph.D.

  7. Example 3:Hutchinson-Gilford Progeria Syndrome http://seattlepi.nwsource.com/specials/seth/190915_progeriaweek.asp CHMI 2227 - E.R. Gauthier, Ph.D.

  8. Ultrastructure of life - the AIDS virus Lipids Nucleic acids Proteins Sugars CHMI 2227 - E.R. Gauthier, Ph.D. http://en.wikipedia.org/wiki/Image:800px-HIV_Viron.png

  9. Lipids Nucleic acids Proteins Sugars Ultrastructure of life - A bacteria http://en.wikipedia.org/wiki/Image:Prokaryote_cell_diagram.svg CHMI 2227 - E.R. Gauthier, Ph.D.

  10. 1- Nucleolus Synthesis of ribosomes 2- Nucleus Contains DNA Site of DNA and RNA synthesis 3- Ribosome Contains RNA and proteins Site of protein sythesis 4 –secretory vesicle Transport 5- rough endoplasmic reticulum Cellular highway 6- Golgi appatarus Cellular highway Sugarland! Ultrastructure of life - A mammalian cell http://en.wikipedia.org/wiki/Image:Biological_cell.svg CHMI 2227 - E.R. Gauthier, Ph.D.

  11. 7- Cytoskeleton Scaffold 8- Smooth endoplasmic reticulum Cellular highway 9- Mitochondria Powerhouse 10 –Vacuole Storage 11- Cytoplasm Cellular Jello 12 – Lysosome Digestive organ of the cell 13 – Centriole Makes flagella/cilia Required during cell division Ultrastructure of life - A mammalian cell http://en.wikipedia.org/wiki/Image:Biological_cell.svg CHMI 2227 - E.R. Gauthier, Ph.D.

  12. Red: mitochondria Blue: Nucleus Green: cytoskeleton http://probes.invitrogen.com/servlets/photo?fileid=g001835&company=probes CHMI 2227 - E.R. Gauthier, Ph.D.

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