2141350 Biological Interactions with Materials

1. 2141350 Biological Interactions with Materials Instructors: Dr. Niti Yongvanich, PhD course coordinator Dr. Pimpon Uttayarat, PhD Textbook: Biomaterials Science: an introduction to materials in medicine/ edited by Buddy D. Ratner, 1st or 2nd Edition, Elsevier. Supplement Reading: Selected journal paper Grading: Dr. Niti Yongvanich 60% Dr. Pimpon Uttayarat 40% (HW 10%, Exam 25%, Part 5%) Contact: pu.cell2008@gmail.com

2. Outline Date Topics 1/8/20011 Introduction 1/15/2011 Proteins, Cells and Tissues 1/22/2011 Host reactions to biomaterials 1/29/2011 Testing materials 2/5/2011 Polymers as biomaterials (cardiovascular prostheses, burn dressings) 2/12/2011Introduction and properties of materials 2/19/2011Introduction to practical aspects of biomaterials 2/26/2011 Midterm

3. Date Topics 3/5/2011 Introduction to practical aspects of biomaterials 3/12/2011 Implants, devices, and biomaterials: Issues unique to this field 3/19/2011 Implants, devices, and biomaterials: Issues unique to this field 3/26/2011 New products and standards. Perspectives and possibilities in Biomaterials Science 4/2/2011 New products and standards. Perspectives and possibilities in Biomaterials Science 4/9/2011 TBA 4/16/2011 Presentation

4. Important definitions A biomaterial is a nonviable material used in a medical device, intended to interact with biological systems. (David Williams, 1987) • biocompatibility: the ability of a material to perform with an appropriate host response in a specific application in the way that it does not provoke rejection by the body • to replace/restore the function of the diseased or damaged tissue • to facilitate the healing with surrounding host tissue • biomaterials include synthetic and natural materials

5. Table 1 Some applications of synthetic materials and modified natural materials in medicine Biomaterials Science p.3

6. Autograft is a tissue transplanted from one part of the body to another in the same individual. Allograftis an organ or tissue transplanted from one individual to another of the same species but different genotype. Xenograftis an organ or tissue taken from one species to an unlike species. Tissue Engineering is an interdisciplinary field that applies the principles of engineering and life sciences toward the development of biological substitutes that restore, maintain, or improve tissue function or a whole organ. (Langer and Vacanti 1993) • therapeutic application or diagnosis application • include the following areas: biomaterials, cells, biomolecules, engineering design, biomechanical aspect of the design and informatics Regenerative medicine is interchangeably used with tissue engineering but strictly speaking the term primarily involves the use of stem cells to restore the tissue/organ function.

7. Useful resource: www.ncbi.nlm.nih.gov

8. Example: search pubmed for fibronectin adsorption

9. Example: search pubmed for a paper when you know the journal title, volume and year Garcίa et al., Mol Biol Cell, 10, 785-798, 1999.

10. Garcίa et al., Mol Biol Cell, 10, 785-798, 1999.

11. Homework due 1/15/11 • Use pubmed to find a journal paper on fibronectin/collagen/vitronectin adsorption. Write a short paragraph summarizing the abstract. • The summary must include: • Title of the paper • The name of the first author • The name of journal, volume and date of publication • The objective of the paper/experiment (1-2 sentences) • The main finding of the paper (2-4 sentences) • Indicate if there’s a full text link to the paper

12. Biomaterials Science • Part II: Materials in Medicine • Proteins, Cells and Tissues Jan 15, 2011 • textbook • Biomaterials Science: An Interdisciplinary Endeavor • Chapter 3