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Structural Assignment and Synthesis of Palau’amine

Structural Assignment and Synthesis of Palau’amine. Toni Rizk. Beauchemin Research Group Department of Chemistry University of Ottawa. 11. 3. 1. 5. 1. Discovered in 1993 by Scheuer et al.

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Structural Assignment and Synthesis of Palau’amine

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  1. Structural Assignment and Synthesis of Palau’amine Toni Rizk Beauchemin Research Group Department of Chemistry University of Ottawa

  2. 11 3 1 5 1

  3. Discovered in 1993 by Scheuer et al. • Isolated from the marine sponge Stylotellaaurantiumfound in the Yap sea, east of Asia off the coast of the Philippines • Categorized in the bisguandinepyrrole-imidazole alkaloidfamily. • Shows significant antifungal, antitumor, and   immunosuppressive activities

  4. Coupling constant (Hz) Dihedral Angle (°)

  5. Interproton distance (A) H11/17 H11/H18 H12/H17 Black bars: Original (cis) configuration White bars: Revised (trans) configuration Grey bars: Experimental values

  6. Interproton distance (A) H11/17 H11/H18 H12/H17 Black bars: Original (cis) configuration White bars: Revised (trans) configuration Grey bars: Experimental values

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