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Structural Assignment and Synthesis of Palau’amine. Toni Rizk. Beauchemin Research Group Department of Chemistry University of Ottawa. 11. 3. 1. 5. 1. Discovered in 1993 by Scheuer et al.
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Structural Assignment and Synthesis of Palau’amine Toni Rizk Beauchemin Research Group Department of Chemistry University of Ottawa
11 3 1 5 1
Discovered in 1993 by Scheuer et al. • Isolated from the marine sponge Stylotellaaurantiumfound in the Yap sea, east of Asia off the coast of the Philippines • Categorized in the bisguandinepyrrole-imidazole alkaloidfamily. • Shows significant antifungal, antitumor, and immunosuppressive activities
Coupling constant (Hz) Dihedral Angle (°)
Interproton distance (A) H11/17 H11/H18 H12/H17 Black bars: Original (cis) configuration White bars: Revised (trans) configuration Grey bars: Experimental values
Interproton distance (A) H11/17 H11/H18 H12/H17 Black bars: Original (cis) configuration White bars: Revised (trans) configuration Grey bars: Experimental values