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Lung Cancer in Never Smokers (NS)

K elsie Thu 1 , Daiana Becker 1 , Raj Chari 2 , Wei Zhang 3 , Calum MacAulay 1 , Adi Gazdar 3 , Stephen Lam 1 , Wan Lam 1 1 BC Cancer Research Centre, Vancouver, Canada, 2 Harvard Medical School, Boston, USA, 3 University of Texas Southwestern , Dallas, USA

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Lung Cancer in Never Smokers (NS)

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  1. Kelsie Thu1, Daiana Becker1, Raj Chari2, Wei Zhang3, Calum MacAulay1, Adi Gazdar3, Stephen Lam1, Wan Lam1 1BC Cancer Research Centre, Vancouver, Canada, 2Harvard Medical School, Boston, USA, 3University of Texas Southwestern, Dallas, USA World Conference on Lung Cancer, Amsterdam 2011 July 4th, 2011 Lung adenocarcinoma genomes of never smokers exhibit a greater extent of genomic instability than those of smokers

  2. Lung Cancer in Never Smokers (NS) • 7th leading cause of cancer death in world Sun S. et al. Nat Rev Cancer 7(10):778-90 (2007)

  3. Frequency of Alterations Copy number profiles generated from Affymetrix SNP 6 arrays

  4. NS Lung Tumors Exhibit Greater Genomic Instability BCCRC p = 0.028 MSKCC dbGaP p = 0.004 p = 0.128

  5. Differentially Altered Regions • 6 minimal common regions of copy number gain specific to NS • 5q • 7p • 16p A2BP1, ABAT, C16orf68, CARHSP1, PMM2, TMEM186 C7orf10, INHBA ABCA13 IL12B, RNF145, UBLCP1 MAT2B

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