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AFBI Bacteriology Branch Veterinary Sciences Division Belfast, Northern Ireland United Kingdom

MHM-2 Sept 2008. Michael Welsh - IFNg bTB Field testing Jim McNair – bTB Infection models. AFBI Bacteriology Branch Veterinary Sciences Division Belfast, Northern Ireland United Kingdom. R = 0.94. 12. 8. ODI MBSE Ab. 4. 0. 0. 10. 20. 30. 40. 50. PM Score.

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AFBI Bacteriology Branch Veterinary Sciences Division Belfast, Northern Ireland United Kingdom

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  1. MHM-2 Sept 2008 Michael Welsh - IFNg bTB Field testing Jim McNair – bTB Infection models AFBI Bacteriology Branch Veterinary Sciences Division Belfast, Northern Ireland United Kingdom

  2. R = 0.94 12 8 ODI MBSE Ab 4 0 0 10 20 30 40 50 PM Score Experimental & Field Investigations of bTB in Northern Ireland • What we know • IFNg testing 2004-08. >50k animals, >460 bTB infected herds (Parallel testing:- skin test / IFNg tested animals). Skin test missing 41% of animals with confirmed disease. • IFNg+ve / skin test –ve animals >>> risk of subsequently being identified as diseased • IgG1 antibody responses correlate with pathology and pathology relates to the frequency of nasal shedding of M. bovis bacilli • Molecular bTB strain typing:- evidence of infected animals negative in multiple tuberculin skin tests (latency or anergy?)

  3. Difference PPD-B- PPD-A Problems and Logistics of delivering large scale CMI based bovine TB testing • Test must be cheap, practical to deliver and accurate • AFBI filed a patent application UK0722128.6 that improves the logistical ability to deliver CMI based diagnostic tests.

  4. What do we need to consider for the future in managing bTB infection in farmed species • How early do we need to detect infection to reduce risk of transmission? • What is the risk associated with failure to detect heavily diseased anergic animals and can we identify an immunological profile of latency? • Can we continue with low frequency testing with imperfect antigens mainly targeting CD4 T-cell responses (multiplexing / proteomic fingerprinting)? • How do the genetics of M. bovis strain types affect virulence & diagnostics? • Animal genetics:- is there a quantitative heritability / risk of disease? • Does our experimentalist outlook match the epidemiological picture within the diseased population? Are all animals susceptible to infection & capable of transmitting infection? • What about other infections? BVD virus – leukopenia / suppression of normal immune responses / Parasites.

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