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Brain Imaging. Structural imaging MRI thin slice, transtemporal plane FLAIR image (fluid attenuated inversion recovery) Volumetry: hippocampus, amygdala 3-D cortical surface analysis Functional imaging SPECT(INIC,IC): 99 m -Tc ECD (ethyl cisteinate dimer)
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Brain Imaging • Structural imaging MRI thin slice, transtemporal plane FLAIR image(fluid attenuated inversion recovery) Volumetry: hippocampus, amygdala 3-D cortical surface analysis • Functional imaging SPECT(INIC,IC): 99m-Tc ECD(ethyl cisteinate dimer) SISCOM(subtraction of ictal SEPCT coregistered to MRI) PET: 18F-FDG(fluoro-deoxyglucose)
3-D Surface Rendering • Focal cortical atrophy in epilepsy with focal cortical dysplasia • Invasive design and mapping • Gyrus-oriented neocortical resection
Functional Deficit Zone 99m-Tc ECD SPECT 18F-FDG PET In TLE In FLE
SISCOM by Analyze(Mayo, MN) Ictal Interictal SPECT MRI SISCOM
PET and MRI fusion PET MRI Fusion