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Supplementary Fig S2

A. MCF-7-EpiR. MCF-7. MCF-7-TaxR. MCF-7. Epirubicin ( h ):. 0. 6. 24. 48. Paclitaxel ( h ):. 0. 6. 24. 48. 0. 8. 24. 48. 0. 8. 24. 48. SIRT6. SIRT6. P-gp(MDR1). P-gp(MDR1). H3K9ac. H3K9ac. H3K56ac. H3K56ac. p27Kip1. p27Kip1. BIM. BIM. β-Tubulin. β-Tubulin.

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Supplementary Fig S2

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  1. A. MCF-7-EpiR MCF-7 MCF-7-TaxR MCF-7 Epirubicin (h): 0 6 24 48 Paclitaxel (h): 0 6 24 48 0 8 24 48 0 8 24 48 SIRT6 SIRT6 P-gp(MDR1) P-gp(MDR1) H3K9ac H3K9ac H3K56ac H3K56ac p27Kip1 p27Kip1 BIM BIM β-Tubulin β-Tubulin Supplementary Figure S2. (A) MCF-7 and MCF-7-EpiR cells were treated with 1 M epirubicin for 0, 6, 24 and 48 h. (B) MCF-7 and MCF-7-TaxR cells were treated with 10 nMpaclitaxel for 0, 6, 24 and 48 h. At the indicated times cells were collected and analyzed by Western blot analysis to determine expression levelsof SIRT6, FOXO3a, p27Kip1, Ac-p53, p53, H3K9ac, H3H56ac, Bim, Ac-α-Tubulin and β-Tubulin SupplementaryFig S2

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