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Simplifying Synthetic Carbohydrate Chemistry for Innovation

This seminar focuses on practical aspects of synthetic carbohydrate chemistry, exploring opportunities for simplification and innovation. Topics include novel glycosidation approaches, selective carbohydrate modifications, and regioselective silylation/tritylation of saccharide alcohols. The ultimate goal is to develop methodologies that are both cost-effective and experimentally efficient. Don't miss out on this insightful session!

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Simplifying Synthetic Carbohydrate Chemistry for Innovation

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  1. FOCUSING ON PRACTICAL ASPECTS OF SYNTHETIC CARBOHYDRATE CHEMISTRY: OPPORTUNITIES FOR SIMPLIFICATION AND INNOVATION ALFONSO IADONISI UniversityofNaples, Federico II DepartmentofChemicalSciences

  2. Carbohydrates are frequently employed precursors in the synthesis of highly functionalized chiral compounds owing to: • Low cost • Broad availability • Density of functional groups and preformed stereo-centres • Advances in carbohydrate synthetic chemistry have been spurred over the last years by the out-break of glycobiology

  3. Advances in glycobiology Interaction of oligosaccharides with suitable receptors plays a key role in many biological processes with relevant therapeutic implications: tumor insurgence, viral and bacterial infections, blood clotting, immune response, etc A growing number of synthetic oligosaccharides are at advanced stages of experimentation as drugs. In addition, numerous oligosaccharide-based lead structures are investigated in an effort towards the development of new therapeutics

  4. General goal: development of methodologies in synthetic carbohydrate chemistry as much practical as possible with respect to experimental simplicity and economicity (also in terms of experimental time). • Research sub-lines • Novel approaches for the glycosidation reaction and application thereof in the synthesis of biologically relevant targets • Development of methodologies for selective modifications of carbohydrates to generate useful saccharide building-blocks for organic synthesis (application not restricted to oligosaccharide synthesis).

  5. REGIOSELECTIVE SILYLATION OF SACCHARIDE PRIMARY ALCOHOLS

  6. REGIOSELECTIVE TRITYLATION OF SACCHARIDE PRIMARY ALCOHOLS

  7. APPLICATION TO ONE – POT ORTHOGONAL PROTECTION SCHEMES

  8. THANKS TO: MARISA SCHIATTARELLA ALESSANDRA RAVIDA’ SILVIA VALERIO ANTONELLO PASTORE MARILENA GIORDANO SERENA TRABONI PROF. EMILIANO BEDINI PROF. MATTEO ADINOLFI

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