1 / 1

IgG-scFv

IgG-scFv is a type of appended IgGs, which are IgG based molecules with additional antigen-binding units. In the format of IgG(H)-scFvs, two scFvs from the same parental antibody are linked to the C terminus of IgG HC.

bellasmith12
Download Presentation

IgG-scFv

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. IgG-scFv IgG-scFv is a type of appended IgGs, which are IgG based molecules with additional antigen-binding units. In the format of IgG(H)-scFvs, two scFvs from the same parental antibody are linked to the C terminus of IgG HC. IgG-scFvs belong to symmetric bispecific IgG-like molecules and there is no chain-mispairing problem during antibody expression. IgG-scFv is bispecifc and tetravalent, 2+2 antigen-binding valency. In some conditions, each Fab and scFv can have different specificity, which will result in tetravalent, trispecific (2+1+1 antigen- binding valency) or tetraspecific (1+1+1+1 antigen-binding valency) molecules. And such molecules can be custom-tailored to meet customers’ specific requirements.

More Related