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The complete guide to antibody drug conjugates linkers

As one of the crucial components for ADC, antibody drug conjugate linker provides a specific bridge for the stable and efficient delivery of the cytotoxic drug to the target cells during the preparation and storage stages of the ADCs. An ideal linker is supposed to provide competent stability in the process of systemic circulation but take into the efficient and rapid release of the cytotoxic drug in an active form inside the tumor cells.

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The complete guide to antibody drug conjugates linkers

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  1. The Complete Guide to Antibody-drug Conjugates Linkers https://www.creative-biolabs.com/adc/

  2. Antibody drug Conjugate Consisting of a desirable monoclonal antibody, an active cytotoxic drug and an appropriate linker, antibody-drug conjugates(ADCs) are considered to be one of the most innovative and efficient cancer therapy, bring about much hope for these patients who fight against cancers with difficulty. As one of the crucial components for ADC, antibody drug conjugate linker provides a specific bridge for the stable and efficient delivery of the cytotoxic drug to the target cells during the preparation and storage stages of the ADCs. An ideal linker is supposed to provide competent stability in the process of systemic circulation but take into the efficient and rapid release of the cytotoxic drug in an active form inside the tumor cells.

  3. 01 02 Non-cleavable linkers Cleavable Linkers Types of linkers 02 03 YOUR TITLE YOUR TITLE YOUR TITLE

  4. 01 Cleavable Linkers Relying on the inherent properties of a cell’s cytoplasmic compartments for selective release of the cytotoxic drug, cleavable linkers are catalyzed by enzymes in the cancer cell where it releases the cytotoxic agent, including pH-sensitive (acid-labile) linkers, disulfide linkers, Protease-sensitive (peptide) linkers, β-glucuronide linkers

  5. 02 03 01 04 β-glucuronide linkers pH-sensitive linkers Disulfide Linker Peptide Linker pH-sensitive (acid-labile) linkers exert a straight-forward mechanism for payload release. β-glucuronide linker has been used for antibody-drug conjugates (ADCs) to deliver amine-containing cytotoxic agents. Disulfide linkers generally non-selectively release the payload drug under the exposure to an altered chemical environment Peptide linkers are a family of protease-sensitivity linkers that have aroused much attention in ADC development Cleavable Linkers

  6. 02 Non-cleavable linkers A non-cleavable linker keeps the drug within the cell

  7. Non-cleavable linkers It retains the linker and the amino acid served as the attachment site on the antibody. A successful release of the cytotoxic drug requires the complete lysosomal proteolysis of the antibody following internalization of the ADC.

  8. Creative Biolabs As an international cooperation, we have established offices all around the globe with more than 200 well-trained full-time scientists and technicians, who work closely with our customers and research partners to develop new medicines for a better, healthier world.

  9. Contact Us 45-1 Ramsey Road, Shirley, NY 11967, USA Email: marketing@creative-biolabs.com

  10. THANKS

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